失血性休克患者血浆C型利钠多肽含量变化的研究  

Changes of Plasma C-Type Natriuretic Peptide Levels inHemorrhagic Shock Patients

作　　者：朱良红[1] 张新路[1] 

机构地区：[1]皖南医学院弋矶山医院,241001

出　　处：《放射免疫学杂志》2000年第4期198-200,共3页Journal of Radioimmanology

摘　　要：目的 :观察失血性休克患者血浆C型利钠多肽的含量变化 ,探讨其在休克发病机制中的作用。方法 :采用放射免疫法测定了30例健康人 ,25例轻度休克、26例中度休克患者血浆C型利钠多肽含量。结果 :轻度休克患者血浆CNP含量明显高于正常对照组(P<0.01) ;中度休克患者血浆CNP含量明显高于正常对照组(P<0.01) ,也明显高于轻度休克组(P<0.01)。结论 :血浆CNP含量增高与失血性休克的严重程度密切相关 ,CNP在失血性休克的发病机制中可能起重要作用。Objective To Study the Changes of plasma C-type natriuretic peptide levels in hemorrhagic shock patieat and its role in the pathogenesis of shock. Methods Plasma C-type natriuretic peptide (CNP) levels were measured in 30 normal subjects, 25 cases of mild hemorrhagic shock (HS) and 26 cases of moderate HS by radioimmunoassay. Results The results showed that plasma CNP levels in patients with mild HS increased significantly as compared with those in the normal subjects (P<0.01). The plasma CNP levels in patients with moderate HS increased markedly as compared with those not only in the controls (P<0.01) but also the mild HS (P<0.01). Conclusions The increase of the plasma CNP levels was closely correlated with the severity of HS. These data suggest that CNP may play an imprtant role in the pathogenesis of HS.

关 键 词：C型利钠多肽 失血性休克 病理 

分 类 号：R605.971[医药卫生—急诊医学]