α-硫辛酸联合甲钴胺治疗糖尿病周围神经病变的疗效及对氧化应激的影响  

Curative effect of α-lipoic acid combined with mecobalamin in the treatment of diabetic peripheral neuropathy and its influence on the oxidative stress

作　　者：黄耀宁 韦洪江[2] 

机构地区：[1]广州市南沙区榄核医院,广州511480 [2]广东省第二人民医院

出　　处：《山东医药》2013年第8期13-15,共3页Shandong Medical Journal

基　　金：广东省社会发展领域科技计划项目(20120318068)

摘　　要：目的观察α-硫辛酸(ALA)联合甲钴胺治疗糖尿病周围神经病变(DPN)的临床疗效,并观察其对氧化应激的影响。方法将72例2型糖尿病并发DPN的患者随机分为观察组和对照组,每组36例。两组均给予甲钴胺治疗,观察组在此基础上加用ALA治疗,共4周。治疗前后,对两组患者行神经病变主觉症状问卷(TSS)评分,检查神经传导速度,检测血清丙二醛(MDA)水平和超氧化物歧化酶(SOD)水平。结果治疗4周后,与对照组比较,观察组TSS评分明显降低(P<0.01),神经传导速度明显加快(P<0.01),血清MDA含量明显降低(P<0.01),SOD活性则明显增加(P<0.01)。结论 ALA联合甲钴胺能显著改善DPN患者的临床症状,增加神经传导速度,减轻氧化应激。Objective To observe the effect of α-lipoic acid （ALA） combined with mecobalamin in the treatment of diabetic peripheral neuropathy （DPN） and its influence on the oxidative stress. Methods 72 patients with DPN were ran- domly divided into observation group and control group with each group of 36 cases, both group receiving intravenously mecobalamin, moreover, the observation group was given intravenously ALA for 4 weeks. The total symptoms scores （TSS）, nerve conduction velocity, serum level of malonaldehyde （MDA） and superoxide dismutase （SOD） were com- pared before and after treatment in both groups. Results Compared with control group, the MDA was significantly de- creased （P 〈 0.01 ）, SOD was significantly increased （P 〈 0.01 ）, the nerve conduction velocity increased significantly （P 〈0.01 ）, the TSS score dropped significantly （P 〈0.01 ） in observation group after treatment of 4 weeks. Conclusion ALA combined with mecobalamin can effectively improve the clinical symptoms, increase nerve conduction velocity and lighten the oxidative stress of the DPN patients.

关 键 词：Α-硫辛酸 甲钴胺 丙二醛 超氧化物歧化酶 糖尿病周围神经病变 

分 类 号：R587.2[医药卫生—内分泌]