非甾体抗炎药相关胃黏膜损伤机制的研究  

Mechanism of nonsteroidal anti-inflammatory drugs induced gastric mucosa injury

作　　者：张志广[1] 陆伟[2] 李熳[1] 闻淑军[1] 季英兰[1] 夏秀丽[1] 

机构地区：[1]天津医科大学第二医院消化内科,300211 [2]天津市第二人民医院

出　　处：《中国综合临床》2013年第4期358-360,共3页Clinical Medicine of China

基　　金：基金项目：天津市卫生局科技基金资助项目（07KG8）

摘　　要：目的探讨非甾体抗炎药（NSAID）相关胃黏膜损伤组织中血管内皮生长因子（VEGF）、丙二醛、缺氧诱导因子-1α（HIF-1α）的表达，进而了解NSAID引起胃黏膜损伤的作用机制。方法收集我院内镜室胃黏膜活检标本114份，其中来自服用NSAID的慢性胃炎伴糜烂及胃溃疡患者70例（NSAID组），余44份标本来自未服用NSAID的慢性浅表性胃炎患者（对照组），应用免疫组织化学方法检测两组胃黏膜组织中VEGF、丙二醛、HIF-1α，结果以阳性率表示。结果NSAID组VEGF阳性表达率明显低于对照组[25．7％（18／70）与54．5％（24／44），）（2=9．70]；而丙二醛和HIF—1α的阳性率明显高于对照组[62．9％（44／70）与27．3％（12／44），χ^2=13．70；45．7％（32／70）与13．6％（6／44），χ^2=12．50]，差异均有统计学意义（P均〈0．05）。结论NSAID药物可能通过降低胃黏膜组织中的VEGF及升高丙二醛、HIF1-α而引起胃黏膜组织的损伤。Objective To study the expression of Vascular Endothelial Growth Factor （VEGF）, Malondialdehyde （MDA） , Hypoxia Inducible Factor-1α （ HIF-1α） in the Non-Steroidal Anti-Inflammatory Drug （NSAID）-associated gastric mucosa injury tissue, and to understand the mechanism of NSAID induced gastric mucosa injury. Methods We collected 114 biopsy specimen of gastric mucosa under endoscope from patients admitted to our hospital, including 70 cases with NSAID-associated chronic erosive gastritis or gastric ulcer （ NSAID group） and 44 cases with chronic superficial gastritis who never take NSAID as controls （ the control group）. Immunohistochemistry technique was used to detect the positive expressions of VEGF, MDA, HIF-1α in patients. Results The positive rate of VEGF expression in the NSADI group was significantly lower than that in the normal control group （25.7% （18/70） vs. 54. 5% （24/44）,χ^2 = 9.70,P 〈0. 05）. The positive rates of MDA and HIF-1α in the NSADI group were significantly higher than these in the normal control group （MDA： 62.9%（44/70） vs. 27. 3% （12/44） ,χ^2 = 13.70,P 〈0.05; HIF-1α ： 45.7% （32/70） vs. 13.6% （6/44）, χ^2= 12. 50, P 〈 0. 05 ）. Conclusion NSAID drugs may induce gastric mucosa injury by decreasing theexpression of VEGF and increase the levels of MDA and HIF-1α in gastric mucosa tissue.

关 键 词：非甾体抗炎药 血管内皮生长因子 丙二醛 缺氧诱导因子-1Α 

分 类 号：R285.5[医药卫生—中药学]