动物内源性多肽CGA-N46生物信息学分析  

Bioinformatics Analysis of Animal Endogenous Peptides CGA-N46

作　　者：李瑞芳[1] 卢研博 陈士华[1] 张慧茹[1] 王彬[1] 熊前程[1] 

机构地区：[1]河南工业大学生物工程学院,河南郑州450001

出　　处：《动物医学进展》2013年第4期43-46,共4页Progress In Veterinary Medicine

基　　金：国家自然科学基金项目(31071922);河南省重点科技攻关计划项目(112102310325);河南工业大学科学研究基金研究生教育创新计划项目(11YJCX44)

摘　　要：抗菌肽是存在于动植物、昆虫、微生物等生物体内,具有抗菌活性的肽类物质。CGA-N46是一种抗真菌多肽。利用生物信息学工具分析CGA-N46,发现CGA-N46等电点为7.38,分子质量为5.363ku,为亲水蛋白,二级结构为α螺旋,有两个磷酸化位点,无糖基化位点、信号肽序列和跨膜区。通过对CGA-N46结构与性质的分析,推测其可能作用于细胞壁或某些生物分子,致使菌体死亡。Antimicrobial peptides are peptides which exist in animals, plants, insects and microbectera, and have antimicrobial activities. CGA-N46 is an antifungal peptide. We comprehensively utilized many kinds of bioinformatics tools to analysis CGA-N46. The results showed that isoelectric point is 7.38, molecular weight is 5. 363 ku. CGA-N46 is hydrophilic protein, and the secondary structure is s-helix. CGA-N46 has two phosphorylation site, no glycosylation sites, no signal peptide sequence and transmembrane domain. Accoriding to the analyzed structure and properties,we predicted that CGA-N46 could kill bactera though cell wall or some biological molecules.

关 键 词：CGA—N46 生物信息学 抗菌肽 

分 类 号：Q31[生物学—遗传学]