大肠埃希菌强毒力岛致病机制研究进展  

Progress on the Pathogenic Mechanism of E. coli HPI

作　　者：卢琴[1] 严玉霖[1] 高洪[1] 高利波[1] 赵汝[1] 李祥峰[1] 邵志勇[1] 臧雅婷[1] 崔艳艳[1] 

机构地区：[1]云南农业大学动物科学技术学院,云南昆明650201

出　　处：《动物医学进展》2013年第4期94-96,共3页Progress In Veterinary Medicine

基　　金：云南省高端科技人才引进计划项目(2009CI125);云南省现代农业生猪产业技术体系建设(云财农[2009]171号);云南省高校科技创新团队支持计划资助(云教科[2011]14号);国家自然科学基金(项31260594)

摘　　要：大肠埃希菌(Escherichia coli)常引起婴儿和幼畜(禽)严重腹泻和败血症。近年来对于大肠埃希菌强毒力岛(HPI)致病机制的研究己有大量文献记载,但大肠埃希菌具体的致病机制目前尚不明确。研究表明耶尔森菌强毒力岛与一些肠道致病菌的致病性密切相关,如大肠埃希菌、沙门菌、克雷伯菌等。引起大肠埃希菌致病的因素多种多样,如气候变化,应激,机体本身状况等。论文就大肠埃希菌HPI的结构基因及其分子致病机制的研究现状进行综述。Escherichia coli often cause severe diarrhea and septicemia in babies and young livestock （poultry）. In recent years,a large number of documents were reported in E. coli HPI pathogenic mechanism, but the specific pathogenic mechanism of E. coli is not clear at present. A number of studies have showed that Yersinia HPI is related to some intestinal pathogenic bacteria, such as E. coli, Salmonella, Klebsiella pneumoniae, etc. E. coli pathogenicity relates variety of factors, such as climate change, stress, the itself status, etc. This review described the research status of E. coli HPI structure gene and molecular patho genic mechanism.

关 键 词：强毒力岛 致病因素 分子致病机制 

分 类 号：S852.614[农业科学—基础兽医学]