系统性红斑狼疮患者心血管疾病危险因素检测分析  

Analysis of serumcardiovascular risk factors detection in systemic lupus erythematosus

作　　者：张涛[1] 

机构地区：[1]彭山县人民医院检验科,四川彭山612766

出　　处：《四川医学》2013年第2期289-291,共3页Sichuan Medical Journal

摘　　要：目的探讨系统性红斑狼疮(SLE)患者心血管疾病危险因素特征及其临床意义。方法对56例SLE患者和50例健康体检者(对照组)的血清同型半胱氨酸(Hcy)、C-反应蛋白(CRP)、甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、载脂蛋白A1(ApoA1)和载脂蛋白B(ApoB)水平进行检测分析。结果 SLE患者血清Hcy、CRP、TG、TC和LDL水平均高于对照组(P<0.05)、HDL和ApoA1水平均低于对照组(P<0.05)。SLE患者高Hcy血症率和血脂异常率分别为76.8%和82.1%。血清Hcy水平与SLEDAI评分和CRP水平呈正相关(P<0.05),与TG水平和TC水平无明显相关性(P>0.05)。结论高Hcy血症是SLE患者心血管疾病的独立危险因素。Objective To study the characteristics and clinical significance of serum cardiovascular risk factors in systemic lupus erythematosus（SLE）.Methods 56 patients with SLE and 50 normal individuals（control group） were enrolled.The level of serum homocysteine（Hcy）,C-reaction protein,triglyceride（TG）,total cholesterol（TC）,low density lipoprotein（LDL）,high density lipoprotein（HDL）,apolipoprotein A1（ApoA1）,apolipoprotein B（ApoB） were determined and analyzed.Results Hcy、CRP、TG、TC and LDL in the patients with SLE were significantly higher than those in control group（P〈0.05）,HDL and ApoA1 were significantly lower（P〈0.05）.The rates of Hcy and abnormal serum lipid was 76.8% and 82.1% respectively.The level of Hcy was positively correlated with systemic supus erythematosus disease activity index（SLEDAI） and CRP（P〈0.05）.The level of serum Hcy was not significantly correlated with TG and TC（P〈0.05）.Conclusion Hcy was independent cardiovascular risk factor in the patients with SLE.

关 键 词：系统性红班狼疮 同型半胱氨酸 血脂 C-反应蛋白 

分 类 号：R593.241[医药卫生—内科学]