儿童慢性扁桃体炎和腺样体肥大与EB病毒的相关性研究  

Distribution of EB virus in children with chronic tonsillitis and adenoid hypertrophy

作　　者：薛晓成[1] 陈晓平[2] 滕伟强[1] 张燚[2] 

机构地区：[1]宁夏医科大学,宁夏银川750004 [2]上海市浦东新区公利医院,上海浦东200120

出　　处：《宁夏医学杂志》2013年第3期224-226,共3页Ningxia Medical Journal

基　　金：上海市浦东新区科技发展基金资助项目(PKJ2012-Y27)

摘　　要：目的探讨EB病毒(EBV)与儿童慢性扁桃体炎和腺样体肥大发病过程中的相关性。方法采用实时荧光定量PCR技术对42例扁桃体和104例腺样体石蜡组织包埋标本进行EBV定量检测。结果在慢性扁桃体炎和腺样体肥大组织标本中,EBV检出阳性率为45.24%(19/42),在腺样体组织中检出阳性率为67.31%(70/104),EBV在扁桃体及腺样体组织中的表达差异有统计学意义(P<0.05);而在不同性别、月龄、病程、胎次的患儿中EBV的感染差异无统计学意义。结论慢性扁桃体炎和腺样体肥大的发生发展与EBV感染密切相关,为慢性扁桃体炎和腺样体肥大的诊治提供了新的思路。Objective To explore distribution of EB virus in children with chronic tonsillitis and adenoid hypertrophy, to inves- tigate the relationship between the EBV and the pathogenesis of chronic tonsillitis and adenoid hypertrophy. Methods This study includ- ed 42 children with chronic tonsillitis and 104 children with adenoid hypertrophy, and all the patients received surgical therapy. The specimens that obtained in operation had been detected the quantity of the EBV by using real - time fluorescent quantitative PCR （ RT - PCR）. Results The positive rate of EBV detected in tonsillar tissue was 45.24% （ 19/42）, and the adenoid tissue was 67.31% （70/104）. The difference of the EBV quantity between the tonsillar tissue and the adenoid tissue was statistically significant （P 〈 0.05）. The quantity of EBV had no relationship with the gender, months of age, disease duration and nationality. Conclusion The EBV relates with the pathogenesis of chronic tonsillitis and adenoid hypertrophy.

关 键 词：腭扁桃体 腺样体 EB病毒 儿童 

分 类 号：R766.18[医药卫生—耳鼻咽喉科]