肝功能相关酶检测在婴儿HCMV感染中的意义  

Significance of Detection of Liver Function Indicators in Infants with Human Cytomegalovirus

作　　者：赖源[1] 朱纯华[1] 刘娜[1] 叶志纯[1] 李梨平[1] 

机构地区：[1]湖南省儿童医院儿科研究所,湖南长沙410007

出　　处：《实用预防医学》2013年第3期362-363,共2页Practical Preventive Medicine

摘　　要：目的探讨丙氨酸氨基转移酶(ALT)、门冬氨酸氨基转移酶(AST)、γ-谷氨酰转移酶(GGT)等生化指标在判断小儿人巨细胞病毒(HCMV)感染中有无肝细胞损伤的参考价值。方法应用荧光定量聚合酶链反应(FQ-PCR)方法检测246例临床疑诊HCMV感染住院患儿血清HCMV-DNA含量,从而将其分为实验组和对照组,并同时检测其ALT、AST、GGT等生化指标。结果巨细胞病毒感染的实验组ALT、AST、GGT均比对照组增高,差异有统计学意义(P<0.05)。结论 ALT、AST、GGT等肝功能相关酶活性升高程度对判断巨细胞病毒感染是否有肝细胞肝脏损害有一定的参考价值,提示在巨细胞病毒感染治疗中注意护肝治疗。Objective To explore the reference value of alanine aminotransferase（ALT）,aspartate aminotransferase（AST） and γ-glutamyl transpeptidase（GGT） in judging the liver injury of human cytomegalovirus（HCMV） infected children.Methods FQ-PCR was used to detect the content of HCMV-DNA in 246 inpatients with suspected HCMV.All inpatients were divided into HCMV infected group and control group according to the detection results;meanwhile,ALT,AST and GGT were determined.Results The levels of ALT,AST and GGT in HCMV infected group were significantly higher than those in control group,and the difference was statistically significant（P0.05）.Conclusion ALT,AST and GGT have a certain reference value in judging the liver injury of children with HCMV,which indicates that more attention should be paid to liver-protecting therapy in HCMV infection.

关 键 词：肝功能指标 HCMV 肝损伤 

分 类 号：R722.13[医药卫生—儿科]