2型糖尿病合并骨质疏松症的相关因素分析  

Relevant Risk Factors for Type 2 Diabetes Mellitus Complicated by Osteoporosis

作　　者：沈浩[1] 胡玲[1] 王倩[1] 陆君[1] 

机构地区：[1]南昌大学第三附属医院内分泌科,南昌330008

出　　处：《实用临床医学（江西）》2013年第1期4-5,9,共3页Practical Clinical Medicine

摘　　要：目的分析2型糖尿病(T2DM)合并骨质疏松症(OP)的骨密度(BMD)变化及相关生化指标的情况。方法将93例T2DM患者按其BMD值分为OP组(n=59)及非OP组(n=34),比较2组年龄、体质指数(BMI)、空腹血糖(FBG)、糖化血红蛋白(HbA1c)、尿微量白蛋白、血钙、血磷和血碱性磷酸酶(ALP)等指标之间的差异,并进行相关性分析。结果 OP组患者的年龄、BMI、BMD、血钙、血磷、血ALP及尿微量白蛋白水平与非OP组相比差异有统计学意义(P<0.05);T2DM患者的BMD与年龄、HbA1c、尿微量白蛋白、血ALP呈负相关,与BMI呈正相关,与FBG无相关性。结论高龄、消瘦、高血碱性磷酸酶、糖尿病肾病均为T2DM合并OP的影响因素。Objective To analyze the changes in bone mineral density（BMD） and relevant bioch-emical markers in patients with type 2 diabetes mellitus（T2DM） complicated with osteoporosis（OP）.Methods According to BMD values,93 patients were divided into OP group（n=59） and non-OP group（n=34）.The age,body mass index（BMI）,fasting blood glucose（FBG）,glycosylated hemoglobin（HbA1c）,urinary microalbumin,serum calcium,serum phosphorus and alkali phosphatase（ALP）were compared between the two groups.The correlation was analyzed.Results There were significant differences in the age,BMI,BMD,serum calcium,serum phosphorus,ALP and urinary microalbumin between OP group and non-OP group（P0.05）.The BMD was negatively correlated with the age,HbA1c,urinary microalbumin and ALP,but positively correlated with BMI in patients with T2DM.There was no correlation between BMD and FBG.Conclusion The risk factors for T2DM complicated with OP include old age,weight loss,high ALP levels and diabetic nephropathy.

关 键 词：2型糖尿病 骨质疏松症 骨密度 生化指标 

分 类 号：R587.1[医药卫生—内分泌]