慢性心力衰竭患者胱抑素C与氨基末端脑钠肽前体的相关性研究  

Correlative Study of Cystatin C and N-terminal Pro Brain Natriuretic Peptide in Patients with Chronic Heart Failure

作　　者：陈默野 刘涛生 郭宏伟 张爱军 

机构地区：[1]湖北省武汉市武昌医院心内科,430063

出　　处：《实用心脑肺血管病杂志》2013年第4期85-86,共2页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的探讨慢性心力衰竭(CHF)患者血清胱抑素C(CysC)与氨基末端脑钠肽前体(NT-proBNP)的相关性。方法选取138例CHF患者作为研究对象,按照NYHA心功能分级标准分为心功能Ⅱ级组54例,心功能Ⅲ级组46例,心功能Ⅳ级组38例。分别检测各组患者血清CysC与血浆NT-proBNP水平,并对两者进行Pearson直线相关性分析。结果 3组患者CysC与NT-proBNP比较,差异均有统计学意义(P<0.05)。Pearson直线相关性分析显示CysC与NT-proBNP呈正相关性(r=0.645,P<0.01)。结论 CHF患者CysC与NT-proBNP具有相关性,可以间接反映心功能状况。Objective To discuss the correlation of serum cystatin C（CysC） and N-terminal pro brain natriuretic peptide（NT-proBNP） in patients with chronic heart failure.Methods 138 cases of CHF patients as the research object,according to the NYHA criteria of cardiac function is divided into heart functionⅡgroup 54 cases,heart function Ⅲ group 46 cases,heart function classⅣgroup 38 cases.The serum CysC and plasma NT-proBNP levels were detected,and the two are Pearson linear correlation analysis.Results Compared 3 groups of patients with CysC and NT-proBNP,the differences were statistically significant（P0.05）.Analysis of Pearson correlation showed that CysC was correlated with NT-proBNP（r=0.645,P0.01）.Conclusion A correlation between CysC and NT-proBNP in patients with CHF,can indirectly reflect the cardiac function status.

关 键 词：胱抑素C 心力衰竭 氨基末端前脑纳肽 

分 类 号：R541.6[医药卫生—心血管疾病]