慢性阻塞性肺疾病继发肺动脉高压患者血清超敏C反应蛋白和内皮素-1及一氧化氮的联合检测意义  

The Clinical Value of Combined Detection of High Sensitive C Reactive Protein and Endothelin-1 and Nitric Oxide in Serum of High Pressure in Patients with Chronic Obstructive Pulmonary Disease Secondary to Pulmonary Artery

作　　者：党颖徐[1] 齐红双[1] 李英[1] 

机构地区：[1]河南大学附属南石医院检验科,河南省南阳市473006

出　　处：《实用心脑肺血管病杂志》2013年第4期93-94,共2页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的探讨血清超敏C反应蛋白、内皮素-1及一氧化氮在慢性阻塞性肺疾病(COPD)继发肺动脉高压患者中的检测意义。方法选择我院COPD患者100例,根据是否合并肺动脉高压分为A、B两组,A组为合并肺动脉高压,B组为未合并肺动脉高压。取清晨空腹肘静脉血,测定血清超敏C反应蛋白、内皮素-1和一氧化氮水平。结果 A组患者血清超敏C反应蛋白、内皮素-1及一氧化氮水平分别较B组高,差异有统计学意义(P<0.05)。结论超敏C反应蛋白、内皮素-1和一氧化氮水平与COPD患者合并肺动脉压升高关系密切,早期检测COPD患者该3项指标,有助于预测患者是否继发肺动脉高压,为临床治疗提供指导。Objective To investigate significance of combined detection of serum high sensitivity C reactive protein,endothelin-1 and nitric oxide in patients with chronic obstructive pulmonary disease（COPD）secondary pulmonary arterial hypertension.Methods According to whether the patients complicated with pulmonary hypertension,we divided 100 patients with COPD into A and B group,the former complicated with pulmonary hypertension while the latter not.Then we detected the levels of high sensitivity C reactive protein,endothelin-1 and nitric oxide in vein.Results The levels of high sensitivity C reactive protein,endothelin-1 and nitric oxide in A group were significantly increased compared with those in B group（P0.05）.Conclusion High sensitivity C reactive protein,endothelin-1 and nitric oxide levels with and COPD in patients with pulmonary hypertension is closely related to early detection of COPD patients,the 3 indexes,helps to predict whether patients with secondary pulmonary hypertension,and provide guidance for clinical treatment.

关 键 词：肺疾病 慢性阻塞性 高血压 肺性 超敏C反应蛋白 内皮素-1 一氧化氮 

分 类 号：R563.9[医药卫生—呼吸系统]