尿白蛋白、转铁蛋白对Ⅱ型糖尿病肾病早期诊断的临床意义  

THE RELATIONSHIP BETWEEN URINARY ALBUMIN EXCRETION AND URINARY EXCRETION OF TRANSFERRING TO DIAGNOSE EARLY DIABETES NEPHROPATHY IN TYPE Ⅱ DIABETES MELLITUS

作　　者：金宪初 葛军 乔德彪[2] 

机构地区：[1]上海海员医院,200080 [2]第二军医大学长海医院,200433

出　　处：《交通医学》2000年第4期351-352,共2页Medical Journal of Communications

摘　　要：目的 :探讨Ⅱ型糖尿病患者早期肾脏损害中白蛋白与转铁蛋白的关系。采用放射免疫分析法 (RIA)检测Ⅱ型糖尿病患者 76例 ,正常对照组 5 2例的 2 4小时尿转铁蛋白 (TRF) ,白蛋白 (ALB)及 2 4小时尿蛋白的含量。结果Ⅱ型糖尿病ALB阳性率 30 % (2 2 / 76 ) ,TRF值阳性率 5 2 .6 % (40 / 76 )均高于正常对照组 ,有显著差异 (P <0 .0 1) ,糖尿病组ALB、TRF之间敏感性比较有显著性差异 (χ2 =4.41,P值 <0 .0 5 )。提示尿白蛋白、转铁蛋白可作为糖尿病肾病早期检测指标 ,而转铁蛋白更敏感。Objective:To investigate the relationship between urinary albumin excretion(ALB) and urinary excretion of transferring(TRF) to diabetic nephropathy in 2DM.Methods:ALB TRF of 24h urinary excretion in 76 case of 2DM with radio immunoassay method.Results:ALB and TRF of 24h urinary excretion are higher than those of the control(P<0.01),and the TRF showed more sensitive the ALB(χ 2=4.41,P<0.05).Conclusions:These results indicate that ALB and TRF maybe a relation of early diabetic nephropathy in 2DM.The TRF is may be more sensitive ALB.

关 键 词：Ⅱ型 糖尿病 肾病 尿白蛋白 尿转铁蛋白 诊断 

分 类 号：R587.104[医药卫生—内分泌]