解偶联蛋白-2与心力衰竭  

Uncoupling Protein 2 and Heart Failure

作　　者：石首军[1] 雷平平[1] 李萍[1] 

机构地区：[1]南昌大学第二附属医院心血管内科,江西南昌330006

出　　处：《心血管病学进展》2013年第2期257-260,共4页Advances in Cardiovascular Diseases

基　　金：国家自然基金(项目批准号:31140019)资助

摘　　要：心力衰竭被认为是一种心肌代谢性疾病,而解偶联蛋白-2是参与心肌生物能量代谢及功能调节的重要分子。解偶联蛋白-2是位于线粒体内膜的一类载体蛋白,能将内膜外H+运回到线粒体基质,导致氧化磷酸化脱偶联。解偶联蛋白-2的轻微脱偶联作用能减少线粒体活性氧生成而发挥细胞保护作用,然而,这种轻微脱偶联作用也将导致心肌细胞生物能量代谢、Ca2+内环境稳定、兴奋-收缩偶联异常,有可能进一步加重心力衰竭及诱发各种心律失常的发生。因此,进一步认清解偶联蛋白-2在心脏的功能作用,适当调节解偶联蛋白-2的表达将有助于临床心力衰竭的治疗。Heart failure is considered to be a myocardial metabolic disease, and uncoupling protein 2 （UCP2） is a important molecule which involved in biological energy metabolism and regulating myocardial functions. UCP2 is one kind of carrier proteins located in the mitochondrial inner membrane, and can transmit H^＋ from intermembrane space to the mitochondria matrix, that will result in oxidative phosphorylation uncoupling. UCP2 play a critical role of cell protection through reducing reactive oxygen species （ ROS）, however, mildly uncoupling effect also resulted in abnormal of myocardial cell biological energy metabolism, Ca^2＋ homeostasis and excited-shrinkage coupling, which could further aggravate heart failure and induce various arrhythmia. As a result, it could contribute to the therapy of cardiac failure that further recognizing the role of UCP2 in heart and reasonably regulating the expression of UCP2.

关 键 词：解偶联蛋白-2 心力衰竭 兴奋-收缩偶联 钙离子 能量代谢 

分 类 号：R541.61[医药卫生—心血管疾病]