SET7/9在2型糖尿病大血管病变中的作用  

The effects of SET7/9 on macrovascular complications in patients with type 2 diabetes

作　　者：陈果[1] 高陈林[1] 徐勇[1] 阳诚[1] 唐小平[1] 夏纪毅[1] 

机构地区：[1]泸州医学院附属医院内分泌科,四川泸州646000

出　　处：《重庆医学》2013年第10期1081-1083,共3页Chongqing medicine

基　　金：国家自然科学基金面上项目(30670980)

摘　　要：目的探讨SET7/9在2型糖尿病大血管病变中的作用。方法随机选取10例2型糖尿病无大血管病变患者(DM组)和10例2型糖尿病并大血管病变患者(DV组),以10名健康志愿者作对照(NC组),分别检测各组外周血中组蛋白甲基化酶SET7/9和炎症因子kappa B(NF-κB)的表达,并比较各组结果。结果与NC组相比,DM组和DV组的SET7/9和NF-κB表达均增高(P<0.05);且DV组较DM增高(P<0.05)。结论糖尿病患者体内存在SET7/9表达失调,这种表达失调进而激活NF-κB可能是2型糖尿病大血管并发症发生、发展的重要表观遗传机制。Objective To explore the role of SET7/9 in the diabetic macrovascular diseases.Methods We randomly selected 10 type 2 diabetes mellitus patiens without macrovascular complications（DM group）,10 type 2 diabetes mellitus patiens with macrovascular complications（DV group） and 10 healthy volunteers（NC group）;and then the expression of histone methyltransferases SET7/9 and factor of inflammatory NF-κB in the peripheral blood were detected and compared in each group.Results The expression of SET7/9 and NF-κB was increased in DM group and DV group compared with NC group（P0.05）,and the expression was increased in DV group compared with DM group（P0.05）.Conclusion There were disorders of SET7/9 expression in diabetic patients,and it would activate NF-κB expression by which may be the important epigenetic mechanism of the occurrence and development of type 2 diabetic macrovascular complications.

关 键 词：糖尿病 2型 大血管病变 表观遗传学 组蛋白甲基化酶 

分 类 号：R587.1[医药卫生—内分泌]