高压氧治疗对中重型颅脑损伤患者急性期脑脊液乳酸脱氢酶、肌酸激酶水平及预后的影响  

Effects of hyperbaric oxygen therapy on levels of lactate dehydrogenase,creatinkinase and prognosis of patients with craniocerebral trauma

作　　者：杨世泉[1] 王水平[1] 夏添[1] 王轶群[1] 

机构地区：[1]解放军第123医院高压氧神经内科,安徽蚌埠230015

出　　处：《淮海医药》2013年第2期112-113,共2页Journal of Huaihai Medicine

基　　金：解放军南京军区科技创新重点课题(092010)

摘　　要：目的观察高压氧治疗对中重型颅脑损伤患者脑脊液乳酸脱氢酶(LDH)、肌酸激酶(CK)的相关性及其治疗结果。方法对70例中重型颅脑损伤急性期患者随机分为对照组和观察组,对照组仅采取药物常规治疗,必要时神经外科手术治疗,观察组在对照组的基础上加用高压氧治疗,比较2组患者治疗前后脑脊液乳酸脱氢酶(LDH)、肌酸激酶(CK)及GCS评分变化情况。结果观察组脑脊液乳酸脱氢酶(LDH)、肌酸激酶(CK)明显低于对照组(P<0.05)。GCS评分明显提高,伤后6个月GOS评分明显增高。结论高压氧治疗可显著降低颅脑损伤急性期患者脑脊液LDH、CK水平,并有满意的近期及远期疗效。Objective To explore effects of hyperbaric oxygen（HBO） therapy on levels of lactate dehydrogenase and creatinkinase in cerebrospinal fluid and prognosis of patients with medium or severe craniocerebral trauma.Methods 70 cases were divided randomly into 2 groups.One was treated with HBO combined with conventional treatment（as HBO group）.The other was treated only with conventional treatment（as control group）.Levels of lactate dehydrogenase and creatinkinase in the HBO group were compared before and after treatment.Results Levels of lactate dehydrogenase and creatinkinase in the HBO group were significantly lower than the control group（P〈0.05）;GCS score and GOS score in the HBO group were significantly higher than those in the control therapy group（P〈0.05）.Conclusion HBO therapy can reduce the levels of lactate dehydrogenase and creatinkinase and improve the prognosis of the patients with craniocerebral trauma.

关 键 词：颅脑损伤 高压氧 乳酸脱氢酶 肌酸激酶 

分 类 号：R651.15[医药卫生—外科学]