胰岛素强化治疗对初诊T2DM患者胰岛β细胞功能、炎症状态的影响  

Effect of gradient intensive insulin treatment on β cell function and inflammatory symptoms in newly diagnosed type 2 diabetes mellitus

作　　者：孙虹云[1] 吴志昊[1] 

机构地区：[1]安徽省蚌埠市第三人民医院肾泌科,233000

出　　处：《淮海医药》2013年第2期116-117,共2页Journal of Huaihai Medicine

摘　　要：目的探讨阶梯式胰岛素强化治疗对初诊2型糖尿病患者胰岛β细胞功能、胰岛素抵抗和炎症状态的影响及机制。方法初诊2型糖尿病患者31例进行为期2周的胰岛素强化治疗和后续10周的预混胰岛素治疗,比较治疗前后的FPG、2hPG、HbA1C、Fc-p、2hcp、TC、TG、hsc-RP、WBC、HDL-C和LDL-C。结果治疗后患者FPG、2hPG、HbA1C显著下降;TG、hsc-RP、WBC均下降;Fc-p、2hcp、HDL-C升高(P<0.05);TC、LDL-C均无明显变化(P>0.05)。结论对血糖明显升高的初诊2型糖尿病患者,短期胰岛素强化治疗及后续数周预混胰岛素皮下注射治疗可有效控制血糖、血脂、明显改善胰岛素β细胞功能并减轻胰岛素抵抗和炎症状态。Objective To study the effects and mechanism of gradient intensive insulin treatment on β cell function,insulin resistance and inflammatory symptoms among newly diagnosed type 2 diabetes mellitus（T2DM）.Methods 31 newly diagnosed T2DM cases were treated with continuous subcutaneous insulin（CSII） for 2 weeks and succedent premixed insulin treatment for 10 weeks.The FPG,2hPG,HbA1C,Fc-P,TC,TG,hsc-RP,WBC,HDL-C and LDL-C between pre-and post-treatment were also compared.Results After the intensive insulin treatment,levels of FPG,2hPG,and HbA1C were significantly lowered.Levels of TG,hsc-RP and WBC descended while Fc-p,2hcp and HDL-C increased（P〉0.05）.TC and LDL-C were not prominently changed（P〉0.05）.Conclusion For the newly diagnosed T2DM with more severe hyperglycemia,short-term gradient intensive treatment and succedent CSII of premixed insulin for several weeks can effectively control hyperglycemia,improve β cell function and relieve IR and inflammation obviously.

关 键 词：糖尿病 2型 胰岛素强化治疗 Β细胞功能 胰岛抵抗 炎症 

分 类 号：R587.1[医药卫生—内分泌]