顽痹清丸联合非甾体抗炎药及改善病情的抗风湿药治疗湿热痹阻型类风湿关节炎  

Curative effect and safety of WANBIQING pills combined with nonsteroidal antiinflammatory drugs and disease modifying antirheumatic drugs in the treatment of rheumatoid arthritis of dampness-heat stagnation type

作　　者：王笑青[1] 张永红[1] 侯宏理[1] 王玉丽[1] 许素琴[1] 曹焱[1] 

机构地区：[1]河南省洛阳正骨医院,河南洛阳471002

出　　处：《中医正骨》2013年第3期41-43,46,共4页The Journal of Traditional Chinese Orthopedics and Traumatology

基　　金：河南省科技发展计划项目(082102310095)

摘　　要：目的:观察顽痹清丸联合非甾体抗炎药及改善病情的抗风湿药治疗湿热痹阻型类风湿关节炎的临床疗效及安全性。方法:将53例湿热痹阻型类风湿关节炎患者随机分为2组,A组患者(25例)采用口服顽痹清丸联合双氯芬酸钠缓释胶囊、甲氨蝶呤片和来氟米特片治疗,B组患者(28例)采用口服安慰剂联合双氯芬酸钠缓释胶囊、甲氨蝶呤片和来氟米特片治疗。治疗8周后比较2组患者类风湿因子、血沉、C反应蛋白、关节疼痛评分变化情况及总体疗效。结果:①2组类风湿因子、血沉、C反应蛋白、VAS评分均较治疗前降低;2组类风湿因子下降幅度比较,差异无统计学意义(t=0.071,P=0.944);A组血沉、C反应蛋白、关节疼痛评分下降幅度均大于B组(t=-5.305,P=0.000;t=-2.847,P=0.001;t=-4.807,P=0.000)。②A组临床疗效优于B组(Z=-2.600,P=0.009)。③A组1例患者出现白细胞计数降低,1例患者出现转氨酶增高,2例患者出现咽喉疼痛;B组1例患者出现转氨酶增高,3例患者出现咽喉疼痛。经对症处理后,2组患者的不良反应均消失。2组患者不良反应发生率比较,差异无统计学意义(χ2=0.000,P=1.000)。结论:采用顽痹清丸联合非甾体抗炎药及改善病情的抗风湿药治疗湿热痹阻型类风湿关节炎,可以有效地降低急性期反应物水平,缓解关节疼痛,疗效确切,且不良反应轻微,值得临床推广应用。Objective：To observe the clinical curative effect and safety of WANBIQING pills combined with nonsteroidal antiinflammatory drugs（NASIDs）and disease modifying antirheumatic drugs（DMARDs）in the treatment of rheumatoid arthritis（RA）of dampness-heat stagnation type.Methods：Fifty-three patients with RA of dampness-heat stagnation type were randomly divided into 2 groups,25 patients in group A were administrated with oral application of WANBIQING pills combined with diclofenac sodium sustained release capsules,methotrexate tablets and leflunomide tablets,while the others in group B were administrated with oral application of placebo combined with diclofenac sodium sustained release capsules,methotrexate tablets and leflunomide tablets.After eight-week treatment the 2 groups were compared with each other in such parameters as rheumatoid factor（RF）,erythrocyte sedimentation rate（ESR）,C-reaction protein（CRP）,changes of joint pain scores and total curative effects.Results：The RF,ESR,CRP and VAS of the 2 groups were all decreased compared with those before the treatment,and there was no statistical difference in decreasing degree of RF between the 2 groups（t=0.071,P=0.944）,while the decreasing degrees of ESR,CRP and joint pain scores in group A were all greater than those in group B（t=-5.305,P=0.000;t=-2.847,P=0.001;t=-4.807,P=0.000）.The clinical curative effect of group A was better than that of group B（Z=-2.600,P=0.009）.One case with decreased white blood count,1 case with increased aminopherase and 2 cases with sore throat were found in group A,while 1 case with increased aminopherase and 3 cases with sore throat were found in group B.All of the adverse reactions disappeared after symptomatic treatment.There was no statistical difference in adverse reaction ratio between the 2 groups（χ2=0.000,P=1.000）.Conclusion：The therapy of WANBIQING pills combined with NASIDs and DMARDs can effectively lower the acute phase reactant level and relieve the pain in joint when it is used

关 键 词：关节炎 类风湿 痹证 顽痹清丸 消炎药 非甾类 抗风湿药 治疗 临床研究性 

分 类 号：R593.22[医药卫生—内科学]