槐白皮和多种降压药联用对高血压大鼠血压的影响  

Studies on the hypotensive effect of huaibaipi combined with a variety of antihypertensive drugs on hypertensive rat model

作　　者：王清[1] 林丽文[1] 陈维刚[1] 李军[1] 王国芳[1] 崔立坤[1] 

机构地区：[1]济宁医学院基础学院,山东济宁272067

出　　处：《济宁医学院学报》2013年第1期25-27,共3页Journal of Jining Medical University

摘　　要：目的用Wistar大白鼠建立高血压模型,探讨槐白皮水提物和多种降压药物(卡托普利、硝苯地平和缬沙坦)联用对高血压大鼠的降压作用。方法 60只正常血压的大鼠连续灌胃6mg/kg的N-硝基-L-精氨酸甲酯(L-NAME)22d,从中筛选出19只高血压大鼠,分为3组,即卡托普利+槐白皮组、硝苯地平+槐白皮组和缬沙坦+槐白皮组,观察槐白皮水提物和3种降压药联用对大鼠血压的影响。结果槐白皮与卡托普利联用后其血压值与给予卡托普利后比较具有显著性差异(P<0.05),槐白皮与硝苯地平、与缬沙坦联用血压值与用硝苯地平、缬沙坦后无显著性差异(P>0.05)。结论槐白皮与卡托普利联用对大鼠高血压模型具有协同降压作用。Objective To explore the hypotensive effect of the water extract of Huaibaipi combined with a variety of antihypertensive drugs on hypertensive rat model, we established hypertensive rat models using N-nitro-L- arginine methyl. Methods The total of 60 wistar rats were continuously lavaged with N-nitro-L-arginine methyl 22 days,and screened 19 hypertensive rats. The hypertensive rats were divided into three groups：the captopril＋ Huaibaipi group, the nifedipine ＋ Huaibaipi group and the valsartan ＋ Huaibaipi group. We observed the effect of 75 % the water of Huaibaipi combined with a variety of antihypertensive drugs on hypertensive rat model. Results The blood pressure significantly decreased after drug combination, compared with former giving medicine （P〈0. 01） ,and the synergistic hypotensive mechanism needs further study. Conclusion The water extract of Huaibaipi combined with a variety of antihypertensive drugs on hypertensive rat model has a very significant synergistic antihypertensive effect.

关 键 词：槐白皮 卡托普利 硝苯地平 缬沙坦 大鼠高血压模型 

分 类 号：R285.5[医药卫生—中药学]