缬沙坦对房颤射频消融术后左房容积结构与功能的影响  

The effect of valsartan on left atrium volume after atrial fibrillation undergone radiofrequency ablation

作　　者：巩光平 孙晓斐[2] 丛培玲[2] 徐勤成[2] 魏子秀[2] 

机构地区：[1]济南大学山东省医学科学院医学与生命科学学院,山东济南250062 [2]济宁医学院附属济宁市第一人民医院,山东济宁272011

出　　处：《济宁医学院学报》2013年第1期41-42,52,共3页Journal of Jining Medical University

摘　　要：目的检测经三维标测房颤射频消融术患者在服用缬沙坦后的临床各项指标,探讨房颤射频消融术后服用缬沙坦降低左房内径减少房颤复发的趋势。方法将40例成功经房颤射频消融术的患者随机分为观察组和对照组,每组各20例,对照组只服用原有治疗基础病药物,观察组应继续口服治疗基础疾病的药物,同时加用缬沙坦80mg,每日1次。观察两组患者在术后1个月、3个月、6个月、9个月心脏超声左房内径的变化、12导联心电图、HOLTER及房颤的复发情况。结果房颤射频消融术后,2组患者的左房内径较术前有一定程度减少,但是两组间在术后1个月、3个月、6个月无明显差异(P>0.05),而在术后9个月差异有显著性(P<0.05),同时对照组和观察组相比,房颤的复发率差异无显著性,但是有趋向于显著性的趋势。结论应用缬沙坦可以减少房颤射频消融术后左房内径、有减少房颤复发趋势。Objective To evaluate the effect of valsartan on the recurrence of atrial fibrillation,as welt as left atrial diameter in patients with atrial fibrillation undergone radiofrequency ablation. Methods 40 patients were selected with atrial fibrillation received radiofrequency ablation. Patients were randomly divided into two group, namely valsartan group and control group, with 20 patients in each group. All patients with other dieseases took the original drug. Patients in valsartan group received valsartan 80mg one time a day. Control group take only the origi- nal drug. It was measured 1 weeks before operation, the postoperative 1 months, 3 months, 6 months,9 months left atrial diameter change. At the same time,it was observed Holter,atrial fibrillation recurrence change.Results After atrial fibrillation radiofrequency ablation, left atrial diameter was significantly reduced in two groups. After 1 months, 3 months, 6 months between the two groups it had no significant difference （P〉0. 05）, but 9 months after operation, there were significant differences （P〈0.05） in two groups. In the pairwise comparison, the recurrence rate of atrial fibrillation was no significant difference （P〉0.05）, which tended to be significant trends. Conclusion Left atrial diameter was significantly reduced in patients which took valsartan. Radiofrequency ablation of atrial fibrillation after taking valsartan had reduced the recurrence rate,but the difference was not significant.

关 键 词：射频消融 房颤 左房内径 缬沙坦 

分 类 号：R541.77[医药卫生—心血管疾病]