乙肝病毒患者Pre-S1Ag与乙肝血清标志物的临床诊断价值  

The clinical value of hepatitis B Virus pre-S1 antigen and the serum markers

作　　者：吴慧强[1] 

机构地区：[1]广东省佛山市高明区人民医院检验科528500

出　　处：《世界最新医学信息文摘》2013年第1期7-8,共2页World Latest Medicine Information Electronic Version

摘　　要：目的分析乙型肝炎病毒（HBV）感染患者中血清Pre-S1Ag、HBV-DNA与HBVM的关系及临床意义。方法收集本院慢性乙肝病毒肝炎患者血清标本343例，应用PCR法检测HBV-DNA含量，ELISA法检测Pre—SlAg、HBVM。结果343份标本中HBv．DNA阳性率为84．2％（289／343），Pre-S1Ag阳性率为79．6％（273／343），HBeAg阳性率为65．1％（223／343）。HBV-DNA与Pre-S1Ag的阳性率无统计学差异、与HBeAg的阳性率差异有统计学意义。120例HBeAg阴性的标本中79例Pre-S1Ag阳性，49例HBV-DNA阳性，两者阳性率差异无统计学意义。结论Pre—S1Ag是一项十分重要的诊断乙肝病毒复制的指标。Objective Analysis the clinical significance of Pre-S1Ag, HBV-DNA and HBVM in patients with hepatitis B virus （ HBV ） infection. Method A total of 343 chronic hepatitis B patients have been collected. HBV maker and Pre-S1Ag were detected by ELISA, and HBV-DNA by PCR. Result The positive rate of HBV-DNA was 84,2% among the 343 patients, and Pre-S1Ag was 79.6%, HBeAg was 65.1%o there is no significant difference between HBV-DNA and Pre-S1Ag, but there is significant difference between HBV-DNA and HBeAg. The positive rate of Pre-S lAg was 65.8% among the 120 patients whose HBeAg were negative, and HBV-DNA was 40.8%. there is no significant difference between Pre-S1Ag and HBeAg. Conclu-sion Pre-S1Ag is a valuable marker for HBV replication.

关 键 词：乙型肝炎病毒 Pre—S1Ag HBEAG HBV-DNA 病毒复制 

分 类 号：R512.62[医药卫生—内科学]