铜绿假单胞菌医院感染流行病学调查及耐药性分析  

Epidemiological investigation and drug resistance analysis of pseudomonas aeruginosa

作　　者：蔡兴俊[1] 吴华[2] 黄奕江[1] 莫濡冰[1] 

机构地区：[1]海南省人民医院呼吸内科,海南海口570311 [2]海南省人民医院检验科,海南海口570311

出　　处：《海南医学》2013年第5期703-705,共3页Hainan Medical Journal

基　　金：海南省自然科学基金(编号:808203)

摘　　要：目的调查我院铜绿假单胞菌感染的流行病学和耐药性变迁,为铜绿假单胞菌(PAE)感染的防治提供依据。方法回顾性分析2010-2011年临床分离的PAE1001株;对泛耐药菌株感染危险因素进行单因素分析。结果从痰标本中分离的PAE菌株最多,占71.2%;PAE主要分布在重症医学科、呼吸内科、神经外科;环丙沙星、庆大霉素、头孢他啶、阿米卡星耐药率下降,头孢曲松、美洛西林耐药率增加;年龄、住院天数、营养不良、机械通气、人工气道、脑梗塞、结构性肺病、广谱抗生素的应用等与泛耐药PAE感染相关(P<0.05);性别、糖尿病与泛耐药PAE感染无明显相关(P>0.05)。结论 PAE感染率及耐药率高,临床应根据药敏结果合理用药。Objective To investigate epidemiology and drug resistance of pseudomonas aeruginosa （PAE）, and provide the basis for the prevention and treatment of PAE infections. Methods 1001 strains from 2010 to 2011 were analyzed retrospectively, and risk factors of PAE infection were analyzed. Results The detection rate of PAE from sputum was the highest, accounting for 71.2%; PAE mainly distributed in critical care department, respiratory de- partment and neurosurgery department; The resistance rates to ciprofloxacin, gentamicin, ceftazidime and amikacin de-clined, and the resistance rates to ceftriaxone, mezlocillin increased; PAE infection was related with age, the time of hospitalization, malnutrition, mechanical ventilation, artificial airway, cerebral infarction, structural lung disease, the application of broad-spectrum antibiotics; no significant correlation with gender, diabetes. Conclusion PAE infec-tion and drug-resistant rates were high; antibiotic should be used rationally, based on susceptibility results of drugs.

关 键 词：铜绿假单胞菌 耐药性 泛耐药 危险因素 

分 类 号：R446.5[医药卫生—诊断学]