骨转移癌患者手术前后血清IL-8、ICTP和PINP检测的临床意义  

Clinical Significance of Measurement the Changes of Serum IL-8,ICTP and PINP Levels Both Before and After Operation in Patients with Bone Metastasis Malignancies

作　　者：李永念 姚加平 

机构地区：[1]连云港市灌云县仁济医院,222200 [2]连云港市灌云县人民医院,222200

出　　处：《放射免疫学杂志》2013年第2期161-162,共2页Journal of Radioimmanology

摘　　要：目的:探讨了骨转移癌患者手术前后血清IL-8、ICTP和PINP水平的变化及临床意义。方法:应用放射免疫分析对31例骨转移癌患者进行了手术治疗前后血清IL-8、ICTP和PINP检测,并与35名正常健康人作比较。结果:骨转移癌患者在手术前血清IL-8、ICTP和PINP水平均非常显著地高于正常人组(P<0.01),经综合治疗6个月后与正常人组比较无显著性差异(P>0.05),且血清IL-8水平与ICTP、PINP水平呈正相关(r=0.5123、0.6012,P<0.01)。结论:检测骨转移癌患者手术前后血清IL-8、ICTP和PINP水平的变化对了解病情、观察疗效和预后判断均具有一定的临床价值。Objective To explore the clinical relevance of measuring serum IL-8, ICTP and PINP levels both before and after op- eration in patients with bone metastasis cancer. Methods Serum IL-8, ICTP and PINP（with RIA） Levels were measured in 31 pa- tients with bone metastasis cancer and 35 controls. Results Before operation, serum IL-8, ICTP and PINP levels were obviously higher than those in controls （P 〈 0.01 ）. After operation for 6 months, the serum levels were no significant difference from those of eontrels（P 〉 0.05）, serum IL-8 Level showed positively correlated with serum ICTP, PINP levels（ r = 0.5123, 0.6012,P 〈 0.01 ） Conclusion Determination of serum IL-8, ICTP and PINP Levels both before and after operation can be applied monitoring morbidi- ty, therapeutic efficacy and prognosis, thus possess definite value clinically.

关 键 词：骨癌 白细胞介素-8 Ⅰ型胶原交联羧基末端肽 Ⅰ型前胶原氨基端前肽 

分 类 号：R692[医药卫生—泌尿科学]