中药钩藤化学成分研究  

Studies on chemical constituents from Uncaria rhynchophylla

作　　者：焦扬[1] 王模强 华丹[1] 赵川[1] 唐铖[1] 金美花[1] 段宏泉[1] 唐生安[1] 

机构地区：[1]天津医科大学药学院,基础医学研究中心,天津市临床药物关键技术重点实验室,天津300070 [2]四川绵竹鸿基制药有限责任公司,绵竹618200

出　　处：《天津医科大学学报》2013年第2期107-109,共3页Journal of Tianjin Medical University

基　　金：天津市自然科学基金资助项目(10JCYBJC15000)

摘　　要：目的:对中药钩藤的化学成分进行分离鉴定。方法:采用硅胶柱色谱、凝胶柱色谱和HPLC制备色谱以及重结晶方法分离纯化得到单体化合物,采用有机波谱方法鉴定化合物结构。结果:从钩藤总生物碱萃取物中分离得到6个化合物,分别鉴定为去氢硬毛钩藤碱N-氧化物、卡达宾、去氢钩藤碱、喜果苷、钩藤碱、异钩藤碱。结论:去氢硬毛钩藤碱N-氧化物为新天然产物。Objective： To study the chemical constituents from Uncaria rhynchophyUa. Methods： Chemical constituents were isolated and purified by repeated column chromatography （silica gel, Toyopearl HW-40C and preparative HPLC）. Their structures were elucidated on the basis of spectral data analysis. Results： Six compounds （1-6） were isolated and their structures were identified by comparison of their spectral data with literature values as follows： Hirsuteine N-oxide （1）, cadambine （2）, corynoxeine （3）, vincoside Lactam （4）, rhyn- chophylline （5）, isorhynchophylline （6）. Conclusion： Hirsuteine N-oxide has been encountered for the first time in natural sources.

关 键 词：钩藤 化学成分 结构鉴定 

分 类 号：R91[医药卫生—药学]