无症状HIV感染者血浆IL-8、NPI、TNF-α、sIL-2R浓度测定的临床意义  

Clinical significance of plasma concentration of IL-8, NPI, TNF-α, sIL-2R of asymptomatic HIV carrier

作　　者：姜枫[1] 张荣欣[1] 顾侦芳[2] 李政伟[2] 王丹妮[2] 张怀亮[2] 邓鑫[1] 梁健[1] 

机构地区：[1]广西中医药大学附属瑞康医院,南宁530011 [2]河南中医学院第一附属医院,郑州450000

出　　处：《中华中医药杂志》2013年第4期1048-1050,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：中国博士后科学基金(No.20080440743);国家自然科学基金(No.30901906)~~

摘　　要：目的:检测无症状人类免疫缺陷病毒(HIV)感染者血浆细胞因子IL-8、NPI、TNF-α、sIL-2R的浓度,并与健康体检者进行比较,评价无症状HIV感染者的免疫激活状态。方法:选取32例未接受治疗的无症状HIV感染者和22名健康体检者,采用酶联免疫吸附法(ELISA)检测血浆中的IL-8、NPI、TNF-α、sIL-2R浓度,比较二者的差异。结果:与健康体检者比较,无症状HIV感染者的IL-8、NPI、TNF-α、sIL-2R血浆浓度均升高,且有差异(P<0.05)。结论:无症状HIV感染者存在以上述指标为标志的免疫激活状态。Objective： Evaluating the immune activation status of asymptomatic HIV carrier by detectiong plasma IL-8,NPI,TNF-α,sIL-2R,comparing with healthy control.Methods： 32 asymptomatic HIV carrier without ART and 22 healthy controls were involved to detecting plasma concentration of IL-8,NPI,TNF-α,sIL-2R with ELISA,analyzed the difference.Results： Plasma concentration of IL-8,NPI,TNF-α,sIL-2R of asymptomatic HIV carrier were higher than these of healthy controls with significant difference（P0.05）.Conclusion： There are immune activation state marked with the above indexes in asymptomatic HIV carriers.

关 键 词：无症状HIV感染 免疫激活 白细胞介素-8 新蝶呤 可溶性白细胞介素-2受体 

分 类 号：R512.91[医药卫生—内科学]