电针对创伤后应激障碍患者静息态脑功能局部一致性特点的影响  

Regional homogeneity method to analyze encephalic functional characteristic of PTSD patients with the treatment of electroacupuncture under resting state

作　　者：杨莎[1] 李波[1] 袁前 王燕真[1] 张虹[1] 

机构地区：[1]成都中医药大学针灸推拿学院,成都610075 [2]都江堰市精神卫生中心,都江堰611833

出　　处：《中华中医药杂志》2013年第4期1102-1106,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然基金面上项目(No.81773321);四川省教育厅科技项目(No.10ZA094)~~

摘　　要：目的:利用局部一致性(ReHo)方法探测创伤后应激障碍患者在静息状态下是否存在着大脑功能异常,探讨电针治疗创伤后应激障碍(PTSD)患者前后大脑功能的变化情况。方法:采用功能磁共振成像(fMRI)技术,在电针治疗前后,利用ReHo分析静息状态下12例PTSD患者的大脑血氧水平依赖(BOLD)信号差异,同时对电针前后PTSD患者的临床监测量表(CAPS)、汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)进行评定。结果:患者在电针治疗后,其左侧额中回、左侧颞上回、右侧额下回、右侧颞中回、右侧岛叶、右侧丘脑、扣带回、海马旁回、楔叶/楔前叶、舌回、尾状核、小脑等脑区BOLD信号局部一致性增高(P<0.05)。结论:电针治疗PTSD患者具有一定效果,其机制可能与调节额叶、颞叶、枕叶、岛叶、边缘系统和小脑等脑区构成的神经环路有关。Objective： The purpose of this study applied regional homogeneity method to analyze encephalic functional characteristic of PTSD patients under resting state.Methods： Functional magnetic resonance imaging was performed in 12 PTSD patients under resting state.Reho method was used to analyze the differences of before and after treatment of electro acupuncture.Meanwhile,CAPS,HAMD and HAMA were evaluated.Results： The following increased Reho brain regions were found in PTSD group compared with the before of treatment of acupuncture： left middle front gyrus,left superior temporal gyrus,right inferior front gyrus,right middle temporal gyrus,right insula gyrus,right thalamus,cingulate gyrus,parahippocampal gyrus,cuneus/ precuneus,lingual gyrus,caudate nucleus,and cerebellum（P0.05）.Conclusion： With electric acupuncture,it was effect to treat PTSD patients.The mechanism may be correlated with front,temporal,insular,occipital,limbic system and cerebellum,they may be relative to reward pathways.

关 键 词：电针 创伤后应激障碍 功能磁共振成像 局部一致性 

分 类 号：R246.6[医药卫生—针灸推拿学]