急性冠脉综合征患者血单核细胞CD36水平研究  

The Levels of CD36 in Blood Monocytes of Patients with Acute Coronary Syndrome

作　　者：李小婷[1] 吕宁[1] 尹小龙[1] 

机构地区：[1]昆明医科大学附属延安医院心内科,云南昆明650051

出　　处：《昆明医科大学学报》2013年第2期75-78,共4页Journal of Kunming Medical University

基　　金：云南省教育厅科研基金资助项目(08C0130)

摘　　要：目的观察急性冠脉综合征患者血CD36+阳性率及变化,研究它与ACS的相关性,探讨ACS易损斑块发生发展可能的机制.方法收集ACS患者52例(急性心肌梗死27例,不稳定性心绞痛25例);稳定性心绞痛(SA)患者22例;正常对照22例.采取静脉血,应用流式细胞术测定研究3组对象CD36+阳性率.结果(1)ACS组患者CD36+阳性率均显著高于SA组和对照组(P<0.05);SA组1患者血CD36+阳性率均高于对照组(P<0.05);(2)以血CD36+阳性率作为诊断ACS的指标,其对应的ROC曲线下面积为0.986,诊断ACS的最佳临界值为76.835%,所对应的灵敏度为95.5%,特异度为97.1%.结论 (1)ACS患者血CD36+阳性率水平显著升高;(2)CD36+阳性率可作为判断ACS较好的临床血清学指标.Objective To observe the changes and positive ratio of CD36 in blood of the patients with acute coronary syndrome （ACS） , explore the correlation between it and ACS, then discuss the possible mechanisms of the occurrence and development of vulnerable plaque. Methods We collected 52 cases of ACS （ 27 cases of AMI and 25 cases of UA）, 22 cases of SA and 22 cases of control. Flow cytometry was used to detect the positive ratio of CD36 of patients in three groups. Results （1） In ACS group, the positive ratio of CD36 was higher than SA group and control group （P〈0.05） . The positive ratio of CD36 in SA group was quite higher than control group （P〈0.05） . （2） When the positive ratio of CD36 was considered as the diagnostic marker, the area under ROS curve was 0.986, the cut off value for the diagnosis of ACS was 76.835%, the sensitivity was 95.5% and the specificity was 97.1%. Conclusions （1） The positive ratio of CD36 in the patients with ACS rises significantly. （2） The positive ratio of CD36 can be used as the good clinical serological index for the early diagnosis of ACS.

关 键 词：急性冠脉综合征 单核细胞 CD36 

分 类 号：R541.4[医药卫生—心血管疾病]