阿仑膦酸钠与雷洛昔芬对牙槽骨吸收的影响  

Alendronate and raloxifene affect alveolar bone resorption

作　　者：陈锦波[1] 刘铁玉[2] 阎美凤[2] 曲晓娟[3] 

机构地区：[1]大连大学附属口腔医院,辽宁省大连市116012 [2]大连大学附属新华医院,辽宁省大连市116012 [3]大连大学医学院口腔医学系,辽宁省大连市116622

出　　处：《中国组织工程研究》2013年第7期1146-1150,共5页Chinese Journal of Tissue Engineering Research

基　　金：辽宁省教育厅高等学校科学研究项目计划(20040055)~~

摘　　要：背景:研究证明阿仑膦酸钠与雷洛昔芬对骨质疏松有抑制作用。目的:建立实验性大鼠骨质疏松及牙槽骨吸收模型,评价阿仑膦酸钠与雷洛昔芬对骨吸收的防治作用。方法:56只雌性SD大鼠建立骨质疏松及牙槽骨吸收的动物模型,实验动物分组:①去势+结扎组和单纯结扎组又分别分为3个亚组:阿仑膦酸钠组、雷洛昔芬组和非用药组。②单纯去势非用药组。③假手术组做空白对照。建模手术后第5日开始灌胃给药,1次/d,治疗3个月。用血生化指标、骨密度测量及组织形态学方法进行药效评价。结果与结论:阿仑膦酸钠治疗组较雷洛昔芬组有更强的降低去势组碱性磷酸酶和血钙的作用;提高去势组骨密度。结果证实阿仑膦酸钠与雷洛昔芬均能减少骨质丢失,从而可以防止骨质疏松及病理性牙槽骨骨吸收,且阿仑膦酸钠作用较好。BACKGROUND： Studies have shown that alendronate and raloxifene can suppress osteoporosis. OBJECTIVE： To evaluate the anti-osteoporesis effect of alendronate and raloxifene in rat models of osteoporosis and alveolar bone resorption. METHODS： Totally 56 female Sprague-Dawley rats were enrolled to establish animal models of osteoporosis and alveoler bone resorption. Ovariectomized＋ligation group and ligation group were respectively divided into three subgroups： alendronate, raloxifene and non-drug groups. Ovariectomized group and sham operation group （blank control） were set. Intragastric administration was performed at 5 days after modeling, once a day, totally for 3 months. Blood biochemical markers, bone mineral density measurement and histomorphological method were done for evaluation of drug effectiveness.RESULTS AND CONCLUSION： As compared with the raloxifene groups, alendronate groups could significantly reduce alkaline phosphatase and serum calcium levels and promote bone mineral density in the ovariectomized rats. It is confirmed that both alendronate and raloxifene can reduce bone loss to prevent osteoporosis and alveolar bone resorption, but alendronate is a better one.

关 键 词：组织构建 口腔组织构建 阿仑膦酸钠 雷洛昔芬 骨密度 骨质疏松 牙槽骨质丢失 省级基金 

分 类 号：R318[医药卫生—生物医学工程]