扩张皮肤移植后的生物力学变化  

Biomechanical changes following expanded skin grafting

作　　者：田宝祥[1] 刘凤彬[1] 杨雄[1] 蔺海龙[1] 刘洋[1] 樊华[1] 魏纯琳[1] 

机构地区：[1]吉化集团公司总医院烧伤整形科(北华大学第二附属医院),吉林省吉林市132022

出　　处：《中国组织工程研究》2013年第7期1185-1188,共4页Chinese Journal of Tissue Engineering Research

摘　　要：背景:应用皮肤软组织扩张器植入正常的皮肤软组织下,通过增加扩张器内的容量,对皮肤表面软组织产生压力,使其扩张产生"额外"的皮肤软组织,已成为皮肤组织工程研究领域的基本技术手段。目的:通过狗皮肤扩张移植模型了解扩张皮肤在移植后的近期和远期的变化规律。方法:随机抽取12只成年狗,在其背部置入150mL的4个扩张器,其中2个不扩张进行对照。测试扩张不同时间后皮肤应力-应变、应力松弛、极限抗拉强度的结果,并对比分析测定结果。结果与结论:经过扩张,皮肤的黏弹性、强度发生明显降低,黏弹性可在移植后6个月恢复,强度恢复较慢。在行皮肤移植后,生物力学的变化仅为暂时现象,可以恢复至正常,临床应给予关注。BACKGROUND： A skin soft tissue dilator is implanted into the normal skin, generating pressure to expand the skin soft tissue to produce ＂extra＂ skin soft tissues by increasing the capacity within the dilator. This technique has become a basic method in skin tissue engineering. OBJECTIVE： To establish a dog model of expanded skin grafting and to observe the short-term and long-term regular patterns following skin expansion and grafting. METHODS： Twelve adult dogs were randomly selected. Four dilators of 150 mL, two of which did not work as controls, were implanted into the back of dogs. Skin stress-strain, stress relaxation, and ultimate tensile strength were detected and compared at different periods after skin expansion. RESULTS AND CONCLUSION： The skin viscoelasticity and intensity reduced significantly after skin expansion. The viscoelasticity could restore the normal value within 6 months, and the intensity, however had a slower recovery. As biomechanical changes occur provisionally and can be restored after skin grafting, a more attention should be paid in clinic.

关 键 词：组织构建 组织构建与生物力学 皮肤移植 生物力学 皮肤黏弹性 扩张器 皮肤应力 应力松弛 抗拉强度 

分 类 号：R318[医药卫生—生物医学工程]