一氧化氮对末端病中骨及韧带的影响  

Nitric oxide effects on the bone and ligaments in enthesiopathy

作　　者：王文军[1] 王丹[1] 鲍捷[1,2] 李盛村[1] 程龙[1] 王国祥[1] 

机构地区：[1]苏州大学,江苏省苏州市215021 [2]苏州大学捷美生物医学工程仪器联合重点实验室,江苏省苏州市215021

出　　处：《中国组织工程研究》2013年第7期1281-1288,共8页Chinese Journal of Tissue Engineering Research

基　　金：江苏省2012年度普通高校研究生科研创新计划项目(CXLX12_0758);2011江苏省省属高校自然科学研究面上项目(11KJD320001)~~

摘　　要：背景:一氧化氮是最重要调节因子,是生物体内分子之间信息传递的重要信息使,是末端病的重要影响因素之一。目的:通过查阅一氧化氮与末端病相关的文章,并综述一氧化氮对末端病的作用。方法:由第一作者通过计算机检索CNKI、HighWire数据库中关于"一氧化氮与末端病"的相关的论文报告。以"一氧化氮,末端病"或"NO,enthesiopathy"为检索词进行检索。选择的文章内容与一氧化氮对末端病的作用有关,同一领域文献则选择近期发表或发表在权威杂志文章。共检索到135篇文章,按纳入和排除标准对文献进行筛选,共纳入43篇文章。结果与结论:虽然关于一氧化氮是否同时参与末端病发病及其修复的过程观点不一致,但是一氧化氮与末端病的发病密切相关。末端病大鼠模型已经证明了反复的机械应力诱导了末端组织结构的炎症病变及变性,但是各个学者关于引起其变化的细胞、分子生物学机制观点不一致。这些因素彼此之间是怎样的一种关系以及与外在负荷与一氧化氮是如何相互影响、相互协同而导致了末端病的产生,目前尚不清楚。BACKGROUND： Nitric oxide is the most important regulatory factor and an important information transmission between biological molecules, which is one of the important influence factors for enthesiopathy.OBJECTIVE： Through viewing articles related to nitric oxide and enthesiopathy, to review the function of nitric oxide on enthesiopathy. METHODS： An online search of CNKI and High Wire databases was performed for articles related to ＂nitric oxide enthesiopathy＂ by the first author. Articles published with the keywords of ＂nitric oxide, enthesiopathy＂ in Chinese and English were included. Articles related to the functions of nitric oxide on enthesiopathy were selected. Articles published recently or in the authorized journals were of priority. A total of 135 articles were collected in the initial research, and 30 of them were retained according to inclusion and exclusion criteria. RESULTS AND CONCLUSION： Although there different views about whether nitric oxide is involved in enthesiopathy and repair process at the same time, nitric oxide is closely related to the pathologic process of enthesiopathy. A rat model of enthesiopathy has proved that repeated mechanical stress can induce the inflammatory disOrder and degeneration of terminal tissues, but scholars about the cell and molecular biological mechanisms are not identical of views. It is unclear about what kind of relations there are between each factors and how external factors and nitric oxide influence these relations to cause enthesiopathy.

关 键 词：组织构建 组织构建学术探讨 末端病 一氧化氮 信号通路 骨 肌腱 韧带 跟腱 关节囊 自由 基 省级基金 

分 类 号：R318[医药卫生—生物医学工程]