糖尿病对听力及耳蜗形态学结构影响的相关因素  

Diabetes mellitus impacts hearing and cochlear morphology

作　　者：魏双平[1] 郭靠山[2] 李瑞玉[2] 李蒙[3] 吴立萍[4] 颜军礼 

机构地区：[1]邢台医学高等专科学校临床系,河北省邢台市054000 [2]邢台医学高等专科学校第二附属医院中西医结合研究所,河北省邢台市054000 [3]武警新疆总队和田地区支队卫生队,新疆维吾尔自治区和田市848011 [4]河北医科大学附属邢台市人民医院检验科,河北省邢台市054031 [5]河北省任县医院,河北省邢台市055150

出　　处：《中国组织工程研究》2013年第7期1305-1312,共8页Chinese Journal of Tissue Engineering Research

基　　金：河北省中医药管理局资助项目(项目编号2012068)~~

摘　　要：背景:糖尿病是多种病因引起以高血糖为特征的代谢紊乱内分泌性疾病,由于患者长期高血糖状态可引起微血管病变,导致患者听力下降、耳鸣。糖尿病与听力损伤的关系密切,糖尿病听力损伤的发病机制可能与糖尿病引起的微血管病变和代谢紊乱有关。目的:从耳蜗微循环、细胞稳态、遗传及衰老等方面了解糖尿病听力损伤的原因,来揭示目前尚未完全明确的糖尿病听力损伤机制,为临床治疗方案的选择和预后的判断提供根据。方法:糖尿病与听力损伤的关系密切,糖尿病听力损伤的发病机制可能与糖尿病引起的微血管病变和代谢紊乱有关。从耳蜗微循环、细胞稳态、遗传及衰老等方面了解糖尿病听力损伤的原因,来揭示目前尚未完全明确的糖尿病听力损伤机制。结果与结论:糖尿病患者听力损伤属于糖尿病微血管病变,耳蜗微循环在听觉生理中起着十分重要的作用,内耳许多疾病与微循环障碍有关,耳蜗微循环障碍引起耳蜗缺血和缺血后再灌注损伤是导致听力损伤的重要原因。BACKGROUND： Diabetes, characterized as hyperglycemia, is a metabolic disorder endocrine disease caused by a variety of causes. The long-term hyperglycemic state can cause microvascular diseases which lead to the hearing loss and tinnitus. Diabetes is closely correlated with hearing impairment, and the pathogenesis of diabetes hearing loss may be related to diabetes-induced microvascular disease and metabolic disorders. OBJECTIVE： To investigate the causes of diabetes hearing loss from the aspects of cochlear microcirculation cell homeostasis, genetic and aging, in order to identify the mechanism of diabetes hearing loss that is yet unclear, and to provide judgment basis for the selection and prognosis of the treatment methods. METHODS： Diabetes was closely related to hearing loss, and the pathogenesis of diabetes hearing loss may be related to diabetes-induced microvascular disease and metabolic disorders. The reasons for diabetes hearing loss were explored from the aspects of cochlear microcirculation, cell homeostasis, genetic and aging in order to identify the mechanism of diabetes hearing loss that has not yet clear. RESULTS AND CONCLUSION： Diabetes hearing loss is a diabetic microangiopathy. Cochlear microcirculation plays an important role in auditory physiology, and many inner ear diseases are correlated with microcirculation Therefore, cochlear microcirculation-induced cochlear ischemia and reperfusion injury is the main reason for diabetes hearing loss.

关 键 词：组织构建 组织构建学术探讨 糖尿病 并发症 听力损伤 特征 耳蜗 耳蜗外毛细胞 微循环 缺血 内耳 毛细血管 微血管病变 神经病变 代谢异常 省级基金 

分 类 号：R318[医药卫生—生物医学工程]