壳聚糖抗肿瘤缓释药物的特征  

Characteristics of chitosan antitumor sustained-release drugs

作　　者：令亚琴[1] 

机构地区：[1]兰州大学基础医学院病理生理学研究所,甘肃省兰州市730000

出　　处：《中国组织工程研究》2013年第8期1489-1496,共8页Chinese Journal of Tissue Engineering Research

摘　　要：背景:肿瘤严重危害人类的健康,应用有效的化学药物治疗具有重要的意义。目的:分析壳聚糖载药缓释系统抗肿瘤的作用机制及治疗效果。方法:分析壳聚糖抗肿瘤药物缓释材料释放药物机制以及抗肿瘤的作用机制,并分析壳聚糖及其衍生物负载多种抗肿瘤药物如阿霉素、表阿霉素、表柔比星、5-氟尿嘧啶、紫杉醇等的特征及抗肿瘤作用效果。结果与结论:壳聚糖抗肿瘤缓释药物材料具有良好的药物缓释性能以及抗肿瘤性能,能够负载各种常用的抗肿瘤药物,可以控制药物释放速率,延长药物作用时间,维持有效的药物浓度,降低药物的毒副作用,并且对肿瘤及组织器官具有靶向性作用,明显提高了化疗药物对肿瘤的治疗作用。BACKGROUND： Tumor is serious harmful to human health, and the application of effective chemical drug therapy has great significance. OBJECTIVE： To analyze the mechanism and the therapeutic effect of drug-loaded chitosan sustained-release system on the treatment of tumor. METHODS： The mechanism and the therapeutic effect of drug-loaded chitosan sustained-release system on the treatment of tumor was analyzed, as well as the characteristics and anti-tumor effect of chitosan and various chitosan-loaded anti-tumor drugs, such as doxorubicin, epirubicin, epirubicin, 5-fiuorouracil and paclitaxeL RESULTS AND CONCLUSION： Chitosan anti-tumor-sustained release drug materials have good drug release properties and anti-tumor properties, it can load variety of commonly used antitumor drugs, control the drug release rate, extend the drug action time, maintain the effective drug concentration and decrease the toxicity and side effects of drugs, it also has targeting effect on tumor and tissues and organs, and it can increase the therapeutic effect of chemotherapeutic drugs on tumor significantly.

关 键 词：生物材料 生物材料学术探讨 抗肿瘤 缓释 药物 壳聚糖 细胞 纳米 去甲斑蝥素 阿霉素 表阿霉素 表柔比星 5-氟尿嘧啶 紫杉醇 叶酸 

分 类 号：R318[医药卫生—生物医学工程]