高选择性M受体阻滞剂治疗高龄BPH患者膀胱过度活动症的疗效及安全性  

The clinical efficacy and safety of high-selected anticholinergic agents in the treatment of senile patients with overactive bladder and benign prostatic hyperplasia

作　　者：王建龙[1] 钟晨阳[1] 万奔[1] 王建业[1] 

机构地区：[1]卫生部北京医院泌尿外科,北京100730

出　　处：《现代泌尿外科杂志》2013年第2期166-168,共3页Journal of Modern Urology

摘　　要：目的探讨高选择性M受体阻滞剂索利那新治疗高龄BPH患者膀胱过度活动症(OAB)的疗效及安全性。方法选取2010年7月至2011年5月于我院泌尿外科门诊就诊、年龄≥75岁、确诊为OAB的BPH患者30例,给予索利那新治疗,每日1次,每次5mg,治疗周期3个月。治疗前后以排尿日记、国际前列腺症状评分(IPSS)、膀胱过度活动症状评分(OABSS)、患者感知膀胱症状情况分级量表(PPBC)、生活质量评分(QOL)为主要疗效指标,对疗效及服药安全性进行评价。结果治疗后的24h平均尿急次数、24h平均排尿次数、夜尿次数及每周尿失禁次数均较治疗前好转;IPSS、OABSS、PPBC、QOL评分均低于治疗前,差异具有统计学意义(均P<0.05)。9例患者出现轻度口干、便秘等不良反应,均能耐受,对症治疗后缓解。2例患者出现排尿困难情况,停药1周并加用α受体阻滞剂后缓解。结论高选择性M受体阻滞剂索利那新治疗高龄BPH患者的膀胱过度活动症疗效较好,不良反应轻,是一种相对安全有效的药物治疗方法。Objective To evaluate the clinical efficacy and safety of high-selected anticholinergic agents（Solifenacin） in the treatment of senile patients with overactive bladder（OAB） and benign prostatic hyperplasia（BPH）.Methods 30 senile patients with OAB and BPH were enrolled,whose age were over 75 years.All patients received 5 mg Solifenacin once daily.During 3 months＇ treatment,all patients recorded urination diary and adverse events.The symptoms of urgency,frequency,nocturia,urine volume,incontinence were evaluated;IPSS,OABSS,PPBC and QOL were analyzed.Results After three months＇ treatment,all indexes were obviously improved（P0.05）.9 cases which reported dry mouth and constipation were improved after therapy.2 cases which reported dysuria were improved after receiving a-blocker treatment.Conclusions High-selected anticholinergic agents（Solifenacin） can be safe and effective in the treatment of OAB patients with BPH.

关 键 词：高选择性M受体阻滞剂 膀胱过度活动症 高龄BPH 索利那新 

分 类 号：R694[医药卫生—泌尿科学]