放射性核素标记Anx Ⅴ细胞凋亡分子成像在肿瘤化疗疗效评估中的价值  

Molecular imaging of cell apoptosis with radio-labeled Anx Ⅴ in the evaluation of tumor response to chemotherapy

作　　者：杨桂芬[1] 朱虹[1] 

机构地区：[1]南京军区南京总医院核医学科,210002

出　　处：《国际医学放射学杂志》2013年第2期155-159,共5页International Journal of Medical Radiology

基　　金：中国博士后科学基金面上资助(2012M512072);南京军区南京总医院课题(2012050)

摘　　要：细胞凋亡是评价肿瘤化疗疗效的一个重要方面,在靶向凋亡的分子成像技术中,核素显像技术是目前最敏感的技术,以放射性核素标记AnxⅤ的凋亡显像技术应用较为广泛。就放射性核素标记AnxV凋亡成像的原理、示踪剂种类、标记法和生物分布特征、体内外研究及临床研究结果进行综述。Cell apoptosis is one of the importants aspect in the evaluation of tumor response to chemotherapy. Among molecular imaging techniques of apoptosis, radio-nuclide imaging is the most sensitive imaging modality. Apoptosis imaging with radio-labeled Anx V has been extensively studied. Principles of apoptosis detection, classification, radiolabeling and biodistribution characteristics of radio-labeled AnxV, and in vitro, vivo and clinical results were reviewed.

关 键 词：分子成像 凋亡 膜联蛋白 放射性核素成像 癌 化疗疗效 

分 类 号：R817[医药卫生—影像医学与核医学]