几种鱼类培养细胞对不同干扰素敏感性的研究  

STUDIES ON THE SENSITIVITY OF SEVERAL FISH CELL LINES TO VARIOUS INTERFERONS

作　　者：张义兵[1] 王铁辉[1] 

机构地区：[1]中国科学院水生生物研究所,武汉430072

出　　处：《海洋湖沼通报》2000年第3期1-5,共5页Transactions of Oceanology and Limnology

基　　金：国家自然科学基金!(No.39870602)

摘　　要：本文研究了四种鱼类培养细胞ＣＩＫ、 ＣＡＢ、 ＧＣＢ、 ＧＲＥ对ＨｕＩＦＮ－ａ， ＣＩＫ、ＣＡＢ、ＧＣＢ、ＧＲＥ、ＦＨＭ等五种鱼类培养细胞干扰素作用的敏感性。这四种鱼类培养细胞对ＨｕＩＦＮ－ａ不敏感，对五种鱼类培养细胞干扰素表现出相对一致的敏感，性差异。其中ＧＲＥ细胞对鱼类干扰素最敏感，其次为ＣＡＢ、ＧＣＢ。ＣＩＫ细胞能产生高滴度的干扰素但对鱼类干扰素不敏感。不同病毒对干扰素作用的敏感性也不同。The interferon sensitivity of four kinds of fish cell lines to HuINF-a and five types of fish interferons, CIK-IFN, CAB-IFN, GCB-IFN, GRE-IFN and FHM-IFN, was investigated. These four cell lines were not sensitive to HuIFN-a but to five fish interferons. There was no difference in the trend of interferon sensitivity of five cell lines to different fish interferons except CIK-IFN. GRE cells showed the most sensitive to fish IFNs, and then CAB cells and GCB cells. CIK cells appeared to have no sensitivity to various fish interferon species. The interferon sensitivity of fish cells differed in different viruses.

关 键 词：鱼类培养细胞系 干扰素 敏感性 

分 类 号：S948[农业科学—水产养殖]