中性粒细胞明胶酶相关脂质运载蛋白早期诊断急性心肌梗死患者急性肾损伤的价值  

Value of neutrophil gelatinase-associated lipocalin for early diagnosis of acute kidney injury in patients with acute myocardial infarction

作　　者：杨威[1] 张金盈[1] 沈德良[1] 王小芳[1] 马翔宇[1] 

机构地区：[1]郑州大学第一附属医院心内科,450052

出　　处：《实用医学杂志》2013年第7期1107-1109,共3页The Journal of Practical Medicine

摘　　要：目的:评价中性粒细胞明胶酶相关脂质运载蛋白(NGAL)诊断急性心肌梗死(AMI)患者发生急性肾损伤(AKI)的价值。方法:选择2012年1-9月于我科就诊行急诊PCI的AMI者38例,测定介入治疗前和术后2、4、8、12、24、48h血清肌酐(Scr)水平以确定发生AKI患者。收集术前和术后2、4、8、12、24h血清标本置于-80℃冰箱,采用ELISA法测定各组血清中NGAL表达水平,观察术后NGAL浓度对AKI的诊断价值。结果:38例患者中7例术后48hScr水平上升至基础值的1.95倍,AKI的发生率为18.4%。AKI组术后2h血清NGAL显著升高并达到峰值,与基础值比较[(97.2±27.8)ng/mLvs(12.4±4.8)ng/mL,P<0.05],差异有统计学意义。结论:NGAL是反映AMI患者术后发生AKI的良好指标且早于Scr。Objective To assess the value of neutrophil gelatinase-associate lipocalin （NGAL） for early diagnosis of acute kidney injury （AKI） in patients with acute myocardial infarction （AMI）. Methods This study was conducted from January 2012 to September 2012, thirty-eight patients were enrolled who had received primary percutaneous coronary intervention therapy. Serum creatinine was determined before and 2,4,8,12,24,48 h after the PCI surgery for the diagnosis of patients who were complicated with acute kidney injury. Serum, before and after the PCI surgery, were collected and stored under -80~C condition. Serum NGAL was determined by ELISA assay and was used to assess the early diagnostic value of AKI. Results Among 38 AMI patients, 7 patients （18.4%）were complicated with AKI. In AKI group, the Scr level was 1.95 times than the base line level 48 h after PCI surgery. Compared with the base line level, the serum NGAL level was significantly increased to the peak level [ （97.2± 27.8）ng/mL vs. （12.4 ±4.8）ng/mL respectively, P 〈 0.05]. Conclusion NGAL may be a good indicator prior to Scr for diagnosis of AKI.

关 键 词：心肌梗死 中性粒细胞明胶酶相关脂质运载蛋白 急诊PCI 急性肾损伤 

分 类 号：R692[医药卫生—泌尿科学] R542.22[医药卫生—外科学]