珠海市社区居民高尿酸血症流行病学调查及其与慢性肾脏病的相关性  

An epidemiological study on the prevalence of hyperuricemia and its relationship with chronic kidney disease in the urban community residents of Zhuhai

作　　者：邵小飞[1] 周洪跃[2] 刘新宇[1] 陈佑明[3] 李宓[4] 梁燕[1] 陈珊莹[5] 李永强[1] Harry Holthofer 邹和群[1] 

机构地区：[1]南方医科大学第三附属医院肾内科,广州市510630 [2]南方医科大学第三附属医院体检中心,广州市510630 [3]南方医科大学第三附属医院检验科,广州市510630 [4]中山大学第五附属医院血液净化中心,广东省珠海市519000 [5]福建医科大学附属漳州市医院肾内科,福建省漳州市363000 [6]BioAnalytical Sciences&National Centre for Sensor Research,Dublin City University,Dublin,Ireland

出　　处：《实用医学杂志》2013年第7期1172-1174,共3页The Journal of Practical Medicine

基　　金：国际肾脏病学会研究与预防委员会资助项目(编号:ISN-COMGAN;2007);广东省科技计划项目(编号:2011B031800386)

摘　　要：目的:了解珠海市社区居民中高尿酸血症(hyperuricemia,HUA)患病率及其与慢性肾脏病(chronic kidney disease,CKD)的关系。方法:选择珠海市城区成年原住居民(n=2135)进行横断面筛查。收集晨尿及抽取空腹血液检测尿液、血生化指标。结果:珠海市社区居民中HUA总患病率为32.41%。CKD总患病率为15.83%。CKD检出率在HUA人群(24.42%)显著高于尿酸正常人群(11.92%),差异有统计学意义(P<0.01)。多元Logistic回归分析显示:血尿酸、年龄、性别、收缩压、空腹血糖、超敏C反应蛋白水平与CKD发病独立相关(P<0.05)。结论:珠海市城区居民HUA及CKD患病率均高于国内其它地区及同一地区7年前的流行病学研究报道。HUA是CKD发病的独立危险因素。Objective To investigate the prevalence of hyperuricemia and its relationship with chronic kidney disease （CKD） in the urban community residents of Zhuhai. Methods The community residents aged over 18 years old（n = 2 135 ） in Wanzai community of Zhuhai, where the original inhabitants was relatively concentrated, were randomly chosen. Related data was obtained by recording health information and physical examination. Fasting blood and urine samples were collected to detect blood and urine parameters. Results The prevalenees of hyperuricemia and CKD in the community residents were 32.41% and 15.83% relatively. The detectable rate of CKD in hyperuricemia population （24.42%） was significantly higher than that in normal uric acid crowd （11.92% ,P 〈 0.01）. Multivariate logistic regression analysis showed that uric acid, age, gender, systolic blood pressure, fasting glucose, high sensitivity C-reactive protein levels were independently associated with the incidence of CKD （P 〈 0.05）. Conclusions The prevalenees of hyperuricemia and CKD in community residents of Zhuhai city were both higher than reports of other areas in China and of the same area 7 years ago. High uric acid was an independent risk factor for the incidence of CKD.

关 键 词：高尿酸血症 慢性肾脏病 横断面筛查 

分 类 号：R692[医药卫生—泌尿科学] R589[医药卫生—外科学]