辅酶Q_(10)眼用微乳原位凝胶的制备与体外特性考察  

Preparation and in vitro Study of Coenzyme Q_(10) Ophthalmic Microemulsion Gel

作　　者：董少华[1,2] 陈鹰[1] 苏卫[3] 胡晓[1,2] 胡静波[3] 

机构地区：[1]广州军区武汉总医院药剂科,430070 [2]湖北中医药大学,武汉430065 [3]南方医科大学研究生学院,广州510515

出　　处：《医药导报》2013年第4期520-524,共5页Herald of Medicine

摘　　要：目的研制辅酶Q10眼用微乳原位凝胶。方法观察室温下滴眼液的流动状态选择凝胶类型;以加入人工模拟泪液后凝胶黏度变化选择凝胶材料以及用量;通过对微乳凝胶理化特性考察,释放度实验,流变学实验来评价辅Q10眼用微乳凝胶的质量。结果最终选择离子型凝胶材料,用量小,室温下为液态,加入人工泪液后,迅速转变为凝胶;微乳凝胶分散后的粒径为30.41 nm;体外释放药物可持续释放24 h;加入人工泪液后表现为假塑性流体。结论研制的辅酶Q10眼用微乳原位凝胶,使用方便,且有缓释作用,适合眼部使用。Objective To prepare Coenzyme Q10 microemulsion gel for topical ocular drug delivery. Methods Gel type was selected by observing the flow state of microemulation-gel at room temperature. Gel material was chosen according to the viscosity changes of microemulation gel after addition of the artificial tear. The microemulation gel quality was evaluated by studying its physiochemieal property, rheologieal and in vitro release characteristics. Results Ionic gel was chosen as the final formulation material. It could be used with a small quantily and it is liquid at room temperature. After added with artificial tears, its viscosity was rapidly increased. After dispersion, the average particle diameter of the microemulsion gel was 30.41 nm. The in vitro release experiment showed that the preparation could continuously released eoenzyme Q10 over 24 h. Rheology found it was aspseudoplastic fluid. Conclusion In this study, the ophthalmic emulsion gel can be sustainedly released, and is suitable for ophthalmic application.

关 键 词：辅酶Q10 微乳 原位凝胶 体外释放 流变学 

分 类 号：R977.3[医药卫生—药品] TQ460.6[医药卫生—药学]