丙戊酸血清浓度监测质控连续性评估与分析  

Continuous Assessment and Analysis of Serum of Valproic Acid

作　　者：周金玉[1] 孙增先[1] 许静[1] 

机构地区：[1]江苏省连云港市第一人民医院临床药学中心,222002

出　　处：《医药导报》2013年第4期534-536,共3页Herald of Medicine

摘　　要：目的对丙戊酸血清浓度监测质控数据进行连续性评估与分析,确定适合该实验室丙戊酸血清浓度监测的质控规则,确保药物浓度监测质量。方法对2011年7～12月丙戊酸质控178个数据采用Levey-Jennings质控图结合Westgard多规则进行统计学分析。结果通过连续性评价发现,丙戊酸质控共发生8次失控,失控率为4.5%,适合该项测定的质控规则是12S/13S/22S/41S/7tr。结论 Levey-Jennings质控图结合Westgard多规则能及时发现各种测定误差,提高测定结果的准确性,更好地实现治疗药物监测的意义。Objective To continuously assess and analyze valproic acid （VPA） via drug monitoring for quality control, to choose the optimal quality control rule which suits our laboratory, and to ensure the quality of drug monitoring. Methods The VPA quality control data were statistically analyzed, by using Levey-Jennings method combined with Westgard rules. Results Continuous assessment showed that 8 control results were out of control. The new quality control rule was 12S/13S/ 22S/41S/7tr. Conclusion The Levey-Jennings method combined with Westgard rules can timely discover the cause of determination errors, increase the accuracy of determination, and is suitable for clinical therapeutic drug monitoring.

关 键 词：丙戊酸 Levey-Jennings质控图 WESTGARD多规则 质量控制 评价 连续性 

分 类 号：R971.4[医药卫生—药品] R969[医药卫生—药学]