10-羟基喜树碱-癸二酸-LDH杂化物的制备及性能  

Synthesis and Characterization of 10-Hydroxyl Camptothecin-Sebacate-LDH Nanohybrid

作　　者：马秀明[1] 庞秀江[1] 全贞兰[1] 侯万国[1] 

机构地区：[1]青岛科技大学化学与分子工程学院生态化工国家重点实验室培育基地,青岛266042

出　　处：《高等学校化学学报》2013年第4期913-918,共6页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:21173135);高等学校博士学科点专项科研基金(批准号:20110131130008);山东省自然科学基金(批准号:2009ZRB01828);山东省泰山学者基金(批准号:ts20070713)资助

摘　　要：采用二次插层法成功制备了10-羟基喜树碱(HCPT)-癸二酸(SC)插层的层状双金属氢氧化物(LDH).先采用共沉淀法制备SC柱撑LDH杂化物(SC-LDH),再在乙醇介质中将HCPT插入LDH层间形成HCPT-SC-LDH纳米杂化物.依据SC和HCPT的分子尺寸和纳米杂化物的通道高度,推测SC分子在层间可能为双层排列,SC分子两端的羧基同时键合在同一个LDH层片表面上;HCPT分子插入(或溶入)SC分子碳氢链形成的疏水区中.所制备的纳米杂化物既可稳定HCPT的内酯环,又可明显提高HCPT的溶解度,还具有明显的药物缓释效果,其释放动力学过程符合准二级动力学方程.The nanohybrid of 10-hydroxyl eamptothecin （HCPT）-sebaeate （SC）-intercalated layered double hydroxide（ LDH）, HCPT-SC-LDH, was prepared by a secondary intercalation method. First, the nanohybrid of SC intercalated MgEA1-NO3 LDH was prepared by a co-precipitation method; second, HCFr was intercala- ted into the LDH＇ s gallery in ethanol medium. According to the gallery height of the SC-LDH sample and the size of SC molecule, a probably morphology of the SC molecules in the gallery of LDH was suggested that the SC molecules arranged as a bilayer structure in which two carboxylate groups of SC molecule combined onto one LDH layer surface. And HCPT was intercalated into the LDH＇ s gallery via hydrophobic interaction. The encapsulated HCPT could keep biologically active lactone structure, and the nanohybrid could improve the HCPT solubility. Moreover, the obtained HCPT-SC-LDH nanocomposites showed obvious controlled release and the release in vitro of HCPT could be fitted with the pseudo-second-order model.

关 键 词：10-羟基喜树碱 层状双金属氢氧化物 癸二酸 纳米杂化物 缓释 

分 类 号：O641.1[理学—物理化学]