甲钴胺联合前列地尔治疗35例糖尿病痛性神经病变的效果观察  

The Observation of the Effect for Mecobalamin Combined with Alprostadil in the Treatment of 35 Patients with Painful Diabetic Neuropathy

作　　者：彭祖江 曾芳馨[1] 刘玉溥[1] 

机构地区：[1]四川省达州市中西医结合医院,四川达州635000

出　　处：《中国医学创新》2013年第9期28-29,共2页Medical Innovation of China

摘　　要：目的:探讨甲钴胺联合前列地尔治疗糖尿病痛性神经病变的疗效。方法:70例糖尿病伴痛性神经病变的患者,随机分成观察组和对照组,观察组采用甲钴胺联合前列地尔治疗,对照组采用硫辛酸治疗。比较两组患者治疗前后自发性神经痛及神经传导速度等指标的差异。结果:治疗前两组患者间疼痛评分比较差异无统计学意义(P>0.05);治疗2周后观察组患者疼痛评分显著低于对照组(P<0.05)。治疗前两组患者间各项神经传导功能指标间比较差异无统计学意义(P>0.05);通过治疗后观察组患者各项神经传导速度均显著高于对照组(P<0.05)。结论:甲钴胺联合前列地尔治疗糖尿病痛性神经病变能有效减轻患者的疼痛程度,改善肢体麻木的状态。@@@@Objective:To investigate the clinical efficacy for mecobalamin combined with alprostadil in the treatment of patients with painful diabetic neuropathy.Method:70 cases of patients with diabetes with painful neuropathy were randomly divided into the observation group and the control group.The observation group was taken with Mecobalamin alprostadil treatment,and the control group was taken with lipoic acid treatment.The differences of the indicators in patients with spontaneous neuropathic pain and nerve conduction velocity before and after treatment were compared.Result:There were no significant difference for patients before treatment in pain score(P>0.05).The pain scores in the observation group after two weeks of treatment were significantly lower than those in the control group(P<0.05).There was no significant difference for patients before treatment(P>0.05).The various nerve conduction velocity of nerve conduction function index in the observation group after treatment were significantly higher than those in the control group(P<0.05).Conclusion:Mecobalamin with alprostadil in the treatment of painful diabetic neuropathy can effectively reduce the patient’s level of pain,and improve the numbness of state.

关 键 词：糖尿病 痛性神经病变 甲钴胺 前列地尔 

分 类 号：R587.2[医药卫生—内分泌]