慢性阻塞性肺疾病伴哮喘患者血清白介素-6及转化生长因子β1水平的临床研究  

Explore Standard of Serum IL-6 and TGF-β1 in the Chronic Obstructive Pulmonary Disease with Asthma Patients

作　　者：高美花[1] 林爱顺[2] 

机构地区：[1]延边大学附属医院,吉林延边133000 [2]吉林省延边第二人民医院

出　　处：《中国医学创新》2013年第9期137-138,共2页Medical Innovation of China

摘　　要：目的:探讨白介素-6(IL-6)及转化生长因子β1(TGF-β1)在慢性阻塞性肺疾病(COPD)伴哮喘患者的作用及相关性。方法:采用酶联免疫法(ELISA)检测48例慢性阻塞性肺疾病伴哮喘患者血清中IL-6和TGF-β1的浓度,并设36例健康者作为对照组。结果:慢性阻塞性肺疾病伴哮喘患者的血清中IL-6与TGF-β1的水平均显著高于对照组,比较差异具有统计学意义(P<0.05)。结论:IL-6与TGF-β1共同参与了COPD伴哮喘的气道炎性反应,在慢性阻塞性肺疾病伴哮喘的发生发展过程中起着重要作用。@@@@Objective:To explore the effect and correlation of IL-6 and TGF-β1 in chronic obstructive pulmonary disease with asthma patients. Method:To detect the concentration of IL-6 and TGF-β1 in serum from 48 cases with ELISA,and 36 healthy people were the control group.Result:Compared with the control group,the concentration of serum IL-6 and TGF-β1 was significantly increased in chronic obstructive pulmonary disease with asthma patients,obviously difference(P<0.05).Conclusion:Both IL-6 and TGF-β1 involve in the airwas inflammatory reaction and plays an important role in the development and progression of COPD with asthma.

关 键 词：慢性阻塞性肺疾病 哮喘 IL-6 TGF-Β1 

分 类 号：R563.9[医药卫生—呼吸系统]