胸苷激酶的研究进展  

Research progress of thymidine kinase

作　　者：刘程[1] 郭果为[1] 叶忠锋[1] 黄晓红[1] 

机构地区：[1]福建师范大学生命科学学院,福建省发育与神经生物学重点实验室,福州350108

出　　处：《生命科学》2013年第4期365-371,共7页Chinese Bulletin of Life Sciences

基　　金：福建省自然科学基金项目(2008J0004,2010J01145);国家自然科学基金项目(31040084);福建省人才建设项目

摘　　要：胸苷激酶(thymidine kinase,TK)是嘧啶核苷酸补救合成途径的重要酶之一,包括两个亚家族:1型TK及2型TK。这两种TK的作用机理相同,都可以将脱氧胸苷磷酸化为脱氧胸苷一磷酸,但两者的蛋白结构及催化底物范围有较大差异。两种TK都与人类及动物的各种疾病,如心肌病、肿瘤等密切相关,它们还影响寄生虫的毒性、生长及繁殖等。Thymidine kinase is one of important enzymes involved in the DNA-salvage pathway, including type 1 and type 2 subfamilies. Both the two kinds of TK can phosphorylate deoxythymidine to deoxythymidine monophosphate through the same mechanism. However, the protein structure and catalytic substrates of them are different. Research has shown that both the two kinds of TK are associated with human and animal diseases, such as cardiomyopathy, tumor, etc. In addition, TK is also involved in the toxicity, growth and reproduction of parasltes.

关 键 词：胸苷激酶 脱氧胸苷 肿瘤 寄生虫 

分 类 号：Q555.7[生物学—生物化学] Q71