3种梅毒血清学检测方法的应用评价  

Evaluation of Three Syphilis Serologic Test Methods

作　　者：袁余[1] 李冬冬[1] 王婷婷[1] 王亮[1] 严薛丹[1] 舒玲[1] 陶传敏[1] 

机构地区：[1]四川大学华西医院实验医学科,成都610041

出　　处：《预防医学情报杂志》2013年第3期242-244,共3页Journal of Preventive Medicine Information

摘　　要：目的探讨3种梅毒血清学试验在梅毒诊断检测中的应用价值。方法对1 552份梅毒阳性血清和1 000份健康体检阴性的血清用梅毒甲苯胺红不加热血清反应素试验(TRUST)、梅毒螺旋体抗体酶联免疫吸附试验(TP-ELISA)、梅毒螺旋体明胶颗粒凝集试验(TPPA)3种方法进行检测。结果 3种方法检测2 552份血清中,TRUST、TP-ELISA、TPPA灵敏度分别为50.5%、99.4%、100%;特异性分别为99.8%、99.9%、100%。3种方法检测1 000份健康体检者血清,TRUST检出2个生物假阳性,TP-ELISA检出1个生物假阳性。结论 TRUST、TP-ELISA、TPPA 3种方法的敏感性、特异性依次增高。Objective To evaluate the application value of three serologic tests in the diagnosis of syphilis.Methods A total of 1 552 syphilis positive sera and 1 000 healthy syphilis negative sera were detected with methods of TRUST,TP-ELISA,and TPPA.Results The sensitivity of TRUST,TP-ELISA and TPPA were 50.5%,99.4% and 1 00% respectively;and the specificity of them were 99.8%,99.9% and 100% respectively.Two false positive sera were found in 1 000 syphilis negative sera with TRUST,while 1 false positive serum was found using TP-ELISA,compared with TPPA.Conclusion The sensitivity and specificity of TRUST,TP-ELISA and TPPA to detect the syphilis increase ordinally.

关 键 词：梅毒 血清学 诊断 

分 类 号：R446.11[医药卫生—诊断学]