参芪花粉片对高原慢性间歇性缺氧暴露期间脱习服的疗效观察  

Curative effect observation of Shenqipollen tablet on deacclimatization during exposure period of the chronic intermittent hypoxia in high altitude regions

作　　者：娄晓敏 张雪峰 周其全[2] 王胜玉[2] 

机构地区：[1]青海省格尔木市人民医院高原医学研究中心,青海格尔木816000 [2]第三军医大学高原医学系高原疾病学教研室及国家教育部高原医学重点实验室

出　　处：《现代预防医学》2013年第7期1227-1229,共3页Modern Preventive Medicine

基　　金：国家科技支撑计划课题(No:2009BAI85B03)

摘　　要：目的探讨参芪花粉片对高原慢性间歇性缺氧暴露期间脱习服的干预效果。方法选择由平原及低海拔地区进入海拔4300m地区工作的中青年健康职工380名,采用每周在海拔4300m室内工作5d,返回海拔2800m的后方基地休养两天的固定公休模式,连续观察在高原暴露3年期间在海拔2800m休养期间高原脱习服症状的发生率及实施参芪花粉片干预的效果。结果高原脱习服的总检出率为82.37%(313/380);其前10位症状的排序及检出率依次为:嗜睡(66.31%)、乏力(42.37%)、头昏(35.78%)、失眠(30.79%)、食欲降低(29.73%)、心烦(29.21%)、全身不适(28.95%)、情绪低落(27.89%)、心慌(27.10%)、胸闷(24.47%)。高原脱习服人群中需要治疗者占全部脱习服检出者的34.18%(107/313)。参芪花粉片对其的干预效果为,服药15d症状完全消失者占92.52%(99/107),其中半年无复发不需继续服药(痊愈)者占78.79%(78/99)、偶有症状出现而自行服药缓解(显效)者占21.21%(21/99),症状无缓解或部分缓解但需经常服药(无效)者占7.48%(8/107)。观察期间未发现药物不良反应发生。结论高原慢性间歇性缺氧暴露下有较高的高原脱习服患病率,参芪花粉片有较好的近期疗效与远期干预效果,是防治高原脱习服的一种有效药物。OBJECTIVE To investigate the intervention effects of Shenqi pollen tablets on deacclimatization during exposure period of chronic plateau intermittent hypoxic hypoxia. METHODS Selected 380 young healthy workers from the plains and low lying areas into the work area altitude 4 300m, with weekly indoor at an altitude of 4 300m for 5 working days, then returned to the elevation of 2 800m fixed base rest mode, continuously observed the intervention effect of Shenqi pollen tablets on symptom occurrence rate of plateau deacclimatization during rest period exposure period of 3 years in the highlands at an altitude of 2 800m. RESULTS The total detectable rate of altitude deacclimatization was 82.37% （313 / 380）; the top 10 symptoms and the order were： lethargy （ 66.31% ） , fatigue （ 42.37% ） , dizziness （ 35.78% ） , insomnia （ 30.79% ） , decreased appetite （29.73%）, upset （29.21%）, general malaise （28.95%）, depression （27.89%）, palpitation （27.10%）, and chest tightness （24.47% ）. The crowd in need of treatment with altitude deacclimatization were detected in the total de-acclimation of those 34.18% （107 / 313）. The intervention effect of Shenqi pollen tablets made the symptoms completely disappear in 92.52% （99 / 107） after medication of 15 days, recurrence rate （cured） was 78.79% （78 / 99） in who without continue medication in half of one year, even？there were some symptoms and self-medication to ease （CR） 21.21% （21 / 99）, free remission or partial remission, but often needed medication （inactive） had 7.48% （8 / 107）. There were no adverse drug reactions during observation period. CONCLUSION The high altitude deacclimatization during exposure period of chronic plateau intermittent hypoxic hypoxia has a higher prevalence. Shenqi pollen tablets have better short-term effect and long-term prevention, and is an effective disease prevention and treatment.

关 键 词：高海拔 返低海拔 高原脱习服 中药 参芪花粉片 干预治疗 

分 类 号：R969.4[医药卫生—药理学]