抗感冒颗粒的处方筛选  

Study on Prescription Screening of Anti-cold Granules

作　　者：付建武[1,2] 涂瑶生[1] 孙冬梅[1] 张建军[1] 施之琪[1] 谢菲[3] 

机构地区：[1]广东省中医研究所,广州510095 [2]广州中医药大学,广州510405 [3]广州军区广州总医院,广州510010

出　　处：《中国药房》2013年第15期1371-1373,共3页China Pharmacy

摘　　要：目的:筛选抗感冒颗粒的处方。方法:以颗粒的成型性、吸湿性和溶解性为评价指标,筛选稀释剂种类、稀释剂配比以及药物与稀释剂配比;以颗粒的口感为指标,确定矫味剂的用量。结果:筛选的处方以糊精和乳糖混合物(4:6,m/m)为稀释剂,药物与稀释剂比为1:1(m/m),以0.05%甜菊素作为矫味剂,90%乙醇作为润湿剂制粒,颗粒休止角为37.98°,临界相对湿度为77%。结论:所选处方合理、可行,制得的颗粒成型性、抗吸湿性和溶解性均较好,可满足生产需求。OBJECTIVE： To screen the prescription of anti-cold granules. METHODS： Using formation, hygroscopicity and solubility as index, the kind and ratio of diluent, and ratio of material to diluent was studied. Using taste as index, the amount of flavoring agent was investigated. RESULTS： The optimum formation process was as follows： dextrin mixed with lactose （4：6, m/ m） as diluent; ratio of material to diluent 1：1 （m/m）; 0.05% steviosin as flavoring agent, 90% ethanol as the wetting agent, the angle of repose 37.98 °, critical relative moisture of 77 %. CONCLUSION： The prescription is feasible and practical, and prepared granule has the good formation, hygroscopicity and solubility. It could be applied for industrial production.

关 键 词：抗感冒颗粒 成型工艺 溶解性 吸湿性 

分 类 号：R284.2[医药卫生—中药学] R283.627[医药卫生—中医学]