中西医结合方案治疗脓毒症的Meta分析  

Integrated Chinese and Western Medicine Scheme for Sepsis:a Meta-analysis

作　　者：张春燕[1] 刘洋[1] 冯婉玉[1] 

机构地区：[1]北京大学人民医院药剂科,北京100044

出　　处：《中国药房》2013年第15期1414-1417,共4页China Pharmacy

摘　　要：目的:系统评价中西医结合方案治疗脓毒症的临床疗效和安全性。方法:查找Cochrane图书馆系统评价资料库、Cochrane协作网对照试验中心注册数据库、MEDLINE、EMBASE、中国知网和万方数据库,全面收集中西医结合方案治疗脓毒症患者的随机对照试验(RCT),使用Revman5.0软件进行Meta分析。结果:本研究纳入文献14篇,共967例患者。中西医结合方案治疗脓毒症的住院病死率[OR=0.41,95%CI(0.26,0.65),P<0.01]、有效率[OR=2.52,95%CI(1.40,4.54),P<0.01]、急性生理学及慢性健康状况评分系统(APACHE)评分[OR=-3.70,95%CI(-6.13,-1.28),P<0.01]、中医辨证评分[MD=-2.03,95%CI(-3.00,-1.06),P<0.01]均优于对照组。结论:中西医结合方案治疗脓毒症有一定的临床疗效。由于纳入的研究数量有限,该系统评价的结果需谨慎对待,尚需更多的设计合理、多中心、大样本的RCT进一步证实。OBJECTIVE： To evaluate clinical efficacy and safety of integrated Chinese and western medicine scheme in the treatment of sepsis systematically. METHODS： Retrieved from Cochrane library, Cochrane Register of Controlled Trials, MEDLINE, Embase, CNKI, Wanfang database, RCTs about integrated Chinese and western medicine scheme for sepsis patients were collected completely. Meta-analysis was conducted using RevmanS.0 software. RESULTS： 14 literatures were included, invovling 967 patients. Mortality[OR=0.41,95%CI（0.26,0.65）,P〈0.01], effective rate[OR=2.52,95%CI（1.40,4.54） ,P〈0.01], APACHE score[OR=-3.70,95%CI（-6.13,-1.28）,P〈0.01] and TCM score [MD=-2.03,95%CI（-3.00,-1.06）,P〈0.01] of integrated Chinese and western medicine group were better than those of control group. CONCLUSION： The integrated Chinese and western medicine scheme is effective in the treatment of sepsis. High-quality large-scale multiple-centered RCTs are required and results of systematic evaluation should be considered carefully, because included studies is limited.

关 键 词：中西医结合治疗 脓毒症 系统评价 

分 类 号：R283[医药卫生—中药学] R969[医药卫生—中医学]