富血小板血浆在软骨修复领域的研究进展  

Research progress of platelet-rich plasma in cartilage regeneration

作　　者：王忠山[1] 秦海燕[2] 赵铱民[1] 

机构地区：[1]第四军医大学口腔医学院,西安710032 [2]解放军第四五四医院口腔科,南京210002

出　　处：《国际生物医学工程杂志》2013年第1期61-64,I0003,共5页International Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目（81200770）;南京军区卫生科研基金资助项目（11MA055）

摘　　要：软骨是缺乏血运的组织，创伤后很难利用自身的间充质干细胞进行修复，难以自愈，持续的关节软骨缺损可引发局部疼痛、水肿反应以及功能障碍、运动受限等其他症状。以往的临床治疗方法包括骨髓刺激法、软骨膜移植、自体软骨细胞移植等，但效果有限。富血小板血浆（PRP）是自体血提取的血小板浓缩物，含有丰富的生长因子及其他组织再生必须的细胞因子，可为软骨细胞生存提供良好的微环境，有望成为促进软骨再生的新方法。Cartilage is vulnerable to traumatic injury and unable to facilitate a satisfactory healing response due to its poor vascularity and inability to access mesenchymal stem cells. Continuous defects in the joint surfaces cause pain, swelling, and mechanical symptoms that result in functional impairment and limitation of athletic participation. Commonly used repair techniques include marrow stimulation, structural osteo-articular autografts or chondroeyte implantation. Platelet-rich plasma （PRP） is a concentrate extract of platelets from autologous blood, which is rich in growth factors and other cytokines and provides local environment for tissue regeneration and lends a possible option for the stimulation and acceleration of cartilage regeneration. This review gives summarization on the current state of the use of PRP for cartilage regeneration .

关 键 词：富血小板血浆 软骨再生 关节软骨 缺损 富血小板凝胶 

分 类 号：R6[医药卫生—外科学]