不同类型疫区狂犬病监测  

Surveillance of rabies in different types of epidemic areas

作　　者：吴秀玲[1] 杨小春[1] 吴泰才[1] 陆裕宽[1] 

机构地区：[1]广西壮族自治区卫生防疫站疫情室,广西南宁53002

出　　处：《疾病控制杂志》2000年第2期109-110,共2页Chinese Journal of Disease Control and Prevention

摘　　要：目的　了解广西地区狂犬病高发年代后的不同类型疫区中家犬自然感染状况和犬伤者狂犬病疫苗免疫后抗体水平 ,为防制狂犬病提供科学依据。方法　对广西狂犬病不同疫区进行病原学和免疫血清学的监测比较。结果　健康犬脑狂犬病毒带毒率 ,持续流行疫区 (11.11% )高于休止期老疫区 (5 .0 % )的 1倍以上。对于狂犬疫苗全程免疫后 (45天 )血清抗体阳性率 ,休止期老疫区(92 .3% )高于持续流行疫区 (75 .0 % )和休止期新疫区 (70 .0 %～ 38.5 % )。这些差异可以反映出一定的地区特点。结论　不同类型疫区狂犬病免疫和预防失败可能是疫苗株和地方株之间缺乏交叉反应所致。Objective To study the rabies prevalence in dogs and antibodies level after immunization in different types of epidemic areas. Methods Comparison of the pathogenic and serological surveillance among the different epidemic areas was used. Results Carrying rates of rabies virus in brain of healthy dogs were 11.11% in the continuous epidemic area, higher than that on the rest stage in the old endemic area(5.0%). The positive rate of rabies antibodies in the sera of people bitten by dogs in 45 days after immunization were determined 92.3%, higher than 75.0% in continuous epidemic area and 38.5% on the rest stage in the new epidemic area. Conclusions Immunization failure in people bitten by dogs in different epidemic areas may be due to lack of the cross reaction between the vaccine strain and epidemic virus strain.

关 键 词：狂犬病 疫区 监测 

分 类 号：R512.990.1[医药卫生—内科学] R373.9[医药卫生—临床医学]