复发性外阴阴道念珠菌病的致病菌种鉴定及药敏试验分析  

Identification and drug sensitivity tests of the pathogenic strains of recurrent vulvovaginal candidiasis

作　　者：周晓维[1] 张振国[1] 刘晓虹[1] 

机构地区：[1]大连市皮肤病医院,辽宁大连116011

出　　处：《中国微生态学杂志》2013年第3期346-347,共2页Chinese Journal of Microecology

摘　　要：目的了解STD门诊复发性外阴道念珠菌病(RVVC)和外阴阴道念珠菌病(VVC)的致病菌种分布及对常用抗真菌药物的敏感状况,为临床治疗提供参考。方法用沙氏琼脂培养基分离纯化菌株,然后用ATB ID 32C酵母菌鉴定系统和ATB Fungus3药敏系统进行菌种鉴定与药物敏感试验。结果 280份标本中检出白色念珠菌201株,占71.79%;非白色念珠菌79株,占28.21%,其中光滑念珠菌42株,占15%。VVC组与RVVC组抗真菌药物比较,VVC组对氟康唑的敏感率高于RVVC组,差异有统计学意义(P<0.05)。结论 STD门诊患者阴道念珠菌病检出菌种仍以白色念珠菌为主,但RVVC组非白色念珠菌比例高于VVC组。非白色念珠菌中光滑念珠菌占比例最高。VVC组氟康唑的敏感率高于RVVC组。Objective To investigate pathogenic strains of recurrent vulvovaginal candidiasis （RVVC） and vulvovaginal candidia- sis （VVC） with STD in the local area, study their sensitivity to common antifungal drugs, and provide the reference for clinical treatment. Methods Strains were isolated with Sabouraud agar medium. Strain identification and drug sensitivity test were performed with ATB ID 32C yeast appraisal system and ATB Fungus3 drug sensitivity system. Results 201 strains of Candida albicans were detected in 280 specimens, accountinged for 71.79%. There were 79 strains of non C. albicans, accounting for 28.21% , and 42 strains of Candida gla- brata （ 15% ）. The sensitive rate of VVC group was higher than that of RVVC group （ P 〈 0.05 ） with statistically significant difference. Conclusion Candida albicans is the predominant pathogen in STD outpatients with VCC, but the positive rate of non C. albieans is high- er in RVVC patients with C. glabrata being predominant. Fluconazole sensitive rate of VVC group is higher than that of RVVC group.

关 键 词：白色念珠菌 非白色念珠菌 抗真菌药物 敏感率 复发外性外阴阴道念珠菌病 

分 类 号：R711.31[医药卫生—妇产科学]