血清降钙素原与超敏C反应蛋白及白介素6在新生儿早期感染中的诊断价值  

Value of procalcitonin hs-CRP and Interleukin-6 in diagnosis of early neonatal infections

作　　者：金胜鑫[1] 石海矾[2] 李伟[2] 

机构地区：[1]温州医学院附属第二医院检验科,浙江温州325027 [2]温州医学院附属第二医院儿科,浙江温州325027

出　　处：《中华医院感染学杂志》2013年第7期1600-1601,1637,共3页Chinese Journal of Nosocomiology

摘　　要：目的探讨血清降钙素原(PCT)、超敏C反应蛋白(hs-CRP)与白介素6(IL-6)在新生儿早期感染中的诊断价值。方法测定67例感染新生儿血清PCT,hs-CRP和IL-6水平,并与非感染组和对照组进行比较,应用受试者工作特征(ROC)曲线进行分析。结果与非感染组和对照组相比,感染组的PCT、hs-CRP与IL-6水平均有不同程度的升高(P<0.01);与对照组相比,非感染组的hs-CRP与IL-6水平呈不同程度的升高(P<0.01),而PCT在两组间差异无统计学意义;PCT、hs-CRP与IL-6的ROC曲线下面积分别为87.9、71.2、83.0,最佳临界值分别为66.0、5.02、97.82pg/ml,灵敏度分别为74.6%、71.4%、80.6%,特异性分别为91.0%、67.2%、68.4%。结论在新生儿早期感染的诊断中,IL-6的灵敏度优于PCT与hs-CRP,而PCT的特异性最好。OBJECTIVE To discuss the value of procalcitonin （PCT） , hypersensitive C-reactive protein （hs-CRP）, and Interleukin-6 （IL-6） in the diagnosis of neonatal infections in the early stage. METHODS The levels of serum PCT ,hs-CRP, and IL-6 of 67 neonates with infections were determined and compared with the neonates without infections and the control cases, the results were analyzed by using the ROC of the participants. RESULTS As compared wish the non-infection group and the control group, the levels of PCT, hs-CRP, and IL-6 of the infection group elevated in varying degrees （P〈 0. 01） . The levels of hs-CRP and IL-6 of the non-infection group also elevated in varying degrees as compared with the control group （P〈 0. 01）, but the difference in the PCT level between the two groups was not statistically significant （PD〉 0. 05）. The serum PCT, hs-CRP and IL-6 area under the ROC curve were 87.9, 71.2, and 83.0, the best thresholds were 66.0, 5.02, and 97.82 pg/mL, the sensitivities were 74.6% ,71.4% ,and 80. 6% , respectively , and the specificities were 91.0% ,67.2%, and 68.4%, respectively. CONCLUSION The sensitivity of the IL-6 is superior to PCT and hs-CRP in the diagnosis of the early neonatal infections, the specificity of the PCT is the best of all.

关 键 词：血清降钙素原 超敏C反应蛋白 白细胞介素6 新生儿早期感染 工作特征曲线 

分 类 号：R181.32[医药卫生—流行病学]